Venous thromboembolism in patients with malignant glioma

Tomohiro Kawaguchi, Toshihiro Kumabe, Masayuki Kanamori, Yoji Yamashita, Yukihiko Sonoda, Mika Watanabe, Teiji Tominaga

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1 Citation (Scopus)


Object: Venous thromboembolism (VTE) is a potentially catastrophic surgical complication that can sometimes lead to cardiopulmonary arrest. Patients with a glioma are known to carry a higher risk for VTE. However, VTE's prevalence among the Japanese population is still unclear and probably underestimated. Here we report our single institution study on VTE and discuss its epidemiology, diagnosis and, prediction modality and prophylaxis. Methods: Clinical data including neurological findings, chemotherapy, irradiation history, and prophylaxis for 316 patients who underwent surgical removal of malignant glioma in our institution from January 1997 and April 2007 was reviewed. Results: Six of the 316 patients (1.9%) developed VTE. The histological diagnosis was glioblastoma in 3, anaplastic astrocytoma in 2, and anaplastic oligodendroglioma in 1 patient. Of these six, two patients died of cardiopulmonary arrest, while four patients recovered uneventfully with (3) or without (1) inferior vena cava filter placement. Plasma D-dimer level was measured in 3 patients, which was elevated in all at the onset and decreased in parallel with their clinical improvement. Conclusion: DVT in the Japanese population after glioma resection appears to be lower than in the Western populations, but further studies are necessary. The plasma level of D-dimer is considered as a possible predictor of VTE.

Original languageEnglish
Pages (from-to)294-299
Number of pages6
JournalJapanese Journal of Neurosurgery
Issue number4
Publication statusPublished - 2009 Apr


  • D-dimer
  • Malignant glioma
  • Pulmonary embolism
  • Venous thromboembolism


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