@article{275cedbbd82f45c599c309a665630f9b,
title = "Vinyldiaminotriazine-acridine conjugate as G-quadruplex alkylating agent",
abstract = "Higher-order structures of nucleic acids have become widely noted for their biological consequences and the discovery of an alkylating small molecule for these structures has been of interest due to its therapeutic potential. We previously developed the vinyldiaminotriazine (VDAT)-acridine conjugate as a T-T mismatch alkylating agent. In this report, we focused on the finding of the alkylation to the G-quadruplex (G4) DNA with VDAT-acridine conjugates. The VDAT-acridine conjugates exhibited a considerable alkylation ability to G4 under mild conditions. Moreover, the investigation of properties with the alkylated G4 revealed that alkylation by this conjugate significantly increased the stability of the G4 structure. This study provides a starting point in the further development of selective G4 alkylating small molecules.",
keywords = "Acridine, Alkylating small molecule, G-quadruplex, Higher-order structures, T-T mismatch, Telomerase",
author = "Hazemi, {Madoka E.} and Kazumitsu Onizuka and Tomohito Kobayashi and Akira Usami and Norihiro Sato and Fumi Nagatsugi",
note = "Funding Information: This work was supported by a Grant-in-Aid for Scientific Research on Innovative Areas {\textquoteleft}{\textquoteleft}Middle Molecular Strategy” (No. JP15H05838) from the Japan Society for the Promotion of Science (JSPS). This work was also supported in part by the research program of “Dynamic Alliance for Open Innovation Bridging Human, Environment and Materials”. The lead author gratefully acknowledges scholarship support throughout master's degree from Sato Yo International Scholarship Foundation (SISF). Funding Information: This work was supported by a Grant-in-Aid for Scientific Research on Innovative Areas {\textquoteleft}{\textquoteleft}Middle Molecular Strategy” ( No. JP15H05838 ) from the Japan Society for the Promotion of Science ( JSPS ). This work was also supported in part by the research program of “Dynamic Alliance for Open Innovation Bridging Human, Environment and Materials”. The lead author gratefully acknowledges scholarship support throughout master{\textquoteright}s degree from Sato Yo International Scholarship Foundation (SISF). Publisher Copyright: {\textcopyright} 2018 Elsevier Ltd",
year = "2018",
month = jul,
day = "23",
doi = "10.1016/j.bmc.2018.05.030",
language = "English",
volume = "26",
pages = "3551--3558",
journal = "Bioorganic and Medicinal Chemistry",
issn = "0968-0896",
publisher = "Elsevier Ltd.",
number = "12",
}