Virus Detection using Second Harmonics of Magnetic Nanoparticles

Ryuichi Hirota; Toru Murayama; Ryota Katsumi; Tokuhisa Kawawaki; Shin Yabukami; Ryuji Igarashi; Yuichi Negishi; Moriaki Kusakabe; Masaki Sekino; Takashi Yatsui; Akihiro Kuwahata

doi:10.1002/tee.23613

Virus Detection using Second Harmonics of Magnetic Nanoparticles

Ryuichi Hirota, Toru Murayama, Ryota Katsumi, Tokuhisa Kawawaki, Shin Yabukami, Ryuji Igarashi, Yuichi Negishi, Moriaki Kusakabe, Masaki Sekino, Takashi Yatsui, Akihiro Kuwahata

Research output: Contribution to journal › Letter › peer-review

3 Citations (Scopus)

Abstract

Virus detection methods based on the nonlinear magnetic response of magnetic nanoparticles have been investigated, and magnetic detection methods using the third harmonic have been widely applied on account of their high sensitivity, short measurement-time, and low cost. In this letter, we propose a virus detection method using the second harmonics to improve the signal intensity. We find that the signal to noise ratio of the second harmonic is approximately three times higher than that of the third harmonic. A comparison of the ratio of the second harmonic to the fourth harmonic (R₂₄) and the ratio of the third harmonic to the fifth harmonic (R₃₅) shows that R₂₄ is more sensitive to identifying changes in virus concentration. Our proposed method has the potential to be utilized for rapid screening on virus detection.

Original language	English
Pages (from-to)	1228-1230
Number of pages	3
Journal	IEEJ Transactions on Electrical and Electronic Engineering
Volume	17
Issue number	8
DOIs	https://doi.org/10.1002/tee.23613
Publication status	Published - 2022 Aug

Keywords

magnetic particle spectroscopy
nonlinear magnetic relaxation
second harmonics
third harmonics
virus detection

ASJC Scopus subject areas

Electrical and Electronic Engineering

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10.1002/tee.23613

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title = "Virus Detection using Second Harmonics of Magnetic Nanoparticles",

abstract = "Virus detection methods based on the nonlinear magnetic response of magnetic nanoparticles have been investigated, and magnetic detection methods using the third harmonic have been widely applied on account of their high sensitivity, short measurement-time, and low cost. In this letter, we propose a virus detection method using the second harmonics to improve the signal intensity. We find that the signal to noise ratio of the second harmonic is approximately three times higher than that of the third harmonic. A comparison of the ratio of the second harmonic to the fourth harmonic (R24) and the ratio of the third harmonic to the fifth harmonic (R35) shows that R24 is more sensitive to identifying changes in virus concentration. Our proposed method has the potential to be utilized for rapid screening on virus detection.",

keywords = "magnetic particle spectroscopy, nonlinear magnetic relaxation, second harmonics, third harmonics, virus detection",

author = "Ryuichi Hirota and Toru Murayama and Ryota Katsumi and Tokuhisa Kawawaki and Shin Yabukami and Ryuji Igarashi and Yuichi Negishi and Moriaki Kusakabe and Masaki Sekino and Takashi Yatsui and Akihiro Kuwahata",

note = "Funding Information: This work was supported by the Adaptable and Seamless Technology Transfer Program (A-STEP) through Target-driven R&D (Grant number: JPMJTR21T4), the Watanabe Foundation, and the Tateisi Science and Technology Foundation. Funding Information: This work was supported by the National Natural Science Foundation of China (No. 61901032). Publisher Copyright: {\textcopyright} 2022 Institute of Electrical Engineers of Japan. Published by Wiley Periodicals LLC.",

year = "2022",

month = aug,

doi = "10.1002/tee.23613",

language = "English",

volume = "17",

pages = "1228--1230",

journal = "IEEJ Transactions on Electrical and Electronic Engineering",

issn = "1931-4973",

publisher = "John Wiley and Sons Inc.",

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TY - JOUR

T1 - Virus Detection using Second Harmonics of Magnetic Nanoparticles

AU - Hirota, Ryuichi

AU - Murayama, Toru

AU - Katsumi, Ryota

AU - Kawawaki, Tokuhisa

AU - Yabukami, Shin

AU - Igarashi, Ryuji

AU - Negishi, Yuichi

AU - Kusakabe, Moriaki

AU - Sekino, Masaki

AU - Yatsui, Takashi

AU - Kuwahata, Akihiro

N1 - Funding Information: This work was supported by the Adaptable and Seamless Technology Transfer Program (A-STEP) through Target-driven R&D (Grant number: JPMJTR21T4), the Watanabe Foundation, and the Tateisi Science and Technology Foundation. Funding Information: This work was supported by the National Natural Science Foundation of China (No. 61901032). Publisher Copyright: © 2022 Institute of Electrical Engineers of Japan. Published by Wiley Periodicals LLC.

PY - 2022/8

Y1 - 2022/8

N2 - Virus detection methods based on the nonlinear magnetic response of magnetic nanoparticles have been investigated, and magnetic detection methods using the third harmonic have been widely applied on account of their high sensitivity, short measurement-time, and low cost. In this letter, we propose a virus detection method using the second harmonics to improve the signal intensity. We find that the signal to noise ratio of the second harmonic is approximately three times higher than that of the third harmonic. A comparison of the ratio of the second harmonic to the fourth harmonic (R24) and the ratio of the third harmonic to the fifth harmonic (R35) shows that R24 is more sensitive to identifying changes in virus concentration. Our proposed method has the potential to be utilized for rapid screening on virus detection.

AB - Virus detection methods based on the nonlinear magnetic response of magnetic nanoparticles have been investigated, and magnetic detection methods using the third harmonic have been widely applied on account of their high sensitivity, short measurement-time, and low cost. In this letter, we propose a virus detection method using the second harmonics to improve the signal intensity. We find that the signal to noise ratio of the second harmonic is approximately three times higher than that of the third harmonic. A comparison of the ratio of the second harmonic to the fourth harmonic (R24) and the ratio of the third harmonic to the fifth harmonic (R35) shows that R24 is more sensitive to identifying changes in virus concentration. Our proposed method has the potential to be utilized for rapid screening on virus detection.

KW - magnetic particle spectroscopy

KW - nonlinear magnetic relaxation

KW - second harmonics

KW - third harmonics

KW - virus detection

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Virus Detection using Second Harmonics of Magnetic Nanoparticles

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