Virus Detection using Second Harmonics of Magnetic Nanoparticles

Ryuichi Hirota, Toru Murayama, Ryota Katsumi, Tokuhisa Kawawaki, Shin Yabukami, Ryuji Igarashi, Yuichi Negishi, Moriaki Kusakabe, Masaki Sekino, Takashi Yatsui, Akihiro Kuwahata

Research output: Contribution to journalLetterpeer-review

3 Citations (Scopus)


Virus detection methods based on the nonlinear magnetic response of magnetic nanoparticles have been investigated, and magnetic detection methods using the third harmonic have been widely applied on account of their high sensitivity, short measurement-time, and low cost. In this letter, we propose a virus detection method using the second harmonics to improve the signal intensity. We find that the signal to noise ratio of the second harmonic is approximately three times higher than that of the third harmonic. A comparison of the ratio of the second harmonic to the fourth harmonic (R24) and the ratio of the third harmonic to the fifth harmonic (R35) shows that R24 is more sensitive to identifying changes in virus concentration. Our proposed method has the potential to be utilized for rapid screening on virus detection.

Original languageEnglish
Pages (from-to)1228-1230
Number of pages3
JournalIEEJ Transactions on Electrical and Electronic Engineering
Issue number8
Publication statusPublished - 2022 Aug


  • magnetic particle spectroscopy
  • nonlinear magnetic relaxation
  • second harmonics
  • third harmonics
  • virus detection

ASJC Scopus subject areas

  • Electrical and Electronic Engineering


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