Visible light-induced photocatalytic and antibacterial activity of N-doped TiO2

Misato Iwatsu, Hiroyasu Kanetaka, Takayuki Mokudai, Toru Ogawa, Masakazu Kawashita, Keiichi Sasaki

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39 Citations (Scopus)


Previous reports of some studies have described that nitrogen (N)-doped titanium dioxide (TiO2) exhibits photocatalytic antibacterial activity under visible light irradiation and that reactive oxygen species (ROS) is involved in its activity. For prevention and treatment of peri-implantitis, an inflammatory lesion caused by the bacterial infection of plaque adhering to the circumference of an implant, we considered that applying N-doped TiO2 to dental implant surfaces can be effective. For this study, we aimed at evaluating visible light-induced antibacterial activity of titanium (Ti) treated with NaOH and hot water, and subsequently heated in an ammonia (NH3) gas atmosphere at 500°C for 3 hr to quantify the generated amount of ROS available for antibacterial activity. N-doped anatase-type titania (TiO2-xNx) is formed on the Ti substrate surface. Under visible light, markedly more hydroxyl radicals were generated with a nitrogen-doped titanium dioxide plate than with a pure titanium plate. Hydrogen peroxide exhibited the same tendency. Furthermore, it showed visible light-induced antibacterial effects over Escherichia coli. Results demonstrate that N-doped TiO2 can be useful as a dental implant surface with low risk of postoperative infection when using visible light irradiation.

Original languageEnglish
Pages (from-to)451-459
Number of pages9
JournalJournal of Biomedical Materials Research - Part B Applied Biomaterials
Issue number2
Publication statusPublished - 2020 Feb 1


  • antibacterial activity
  • nitrogen-doped titanium dioxide
  • peri-implantitis
  • reactive oxygen species
  • visible light


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