Visualization of histamine H1 receptors in dog brain by positron emission tomography

Kazuhiko Yanai; Takehiko Watanabe; Jun Hatazawa; Masatoshi Itoh; Kazuo Nunoki; Kentaro Hatano; Ren Iwata; Kiichi Ishiwata; Tatsuo Ido; Taiju Matsuzawa

doi:10.1016/0304-3940(90)90244-4

Visualization of histamine H₁ receptors in dog brain by positron emission tomography

Kazuhiko Yanai, Takehiko Watanabe, Jun Hatazawa, Masatoshi Itoh, Kazuo Nunoki, Kentaro Hatano, Ren Iwata, Kiichi Ishiwata, Tatsuo Ido, Taiju Matsuzawa

Cyclotron and Radioisotope Center (CYRIC)

Tohoku University

Research output: Contribution to journal › Article › peer-review

17 Citations (Scopus)

Abstract

Histamine H₁ receptors were visualized in the living dog brain using [¹¹C]pyrilamine or [¹¹C]doxepin by positron emission tomography (PET). The regional distribution of these carbon-11 labeled compounds in the brain corresponded well with that of the histamine H₁ receptors separately determined by in vitro binding assay. The radioactivity in the brain was reduced by treatment with triprolidine (1 mg/kg), a histamine H₁ antagonist. The results of our study indicate that it is feasible to visualize histamine H₁ receptors in human brain using these ¹¹C-labeled compounds and PET.

Original language	English
Pages (from-to)	41-44
Number of pages	4
Journal	Neuroscience Letters
Volume	118
Issue number	1
DOIs	https://doi.org/10.1016/0304-3940(90)90244-4
Publication status	Published - 1990 Oct 2

Keywords

Dog
Histamine
Histamine H receptor
In vivo study
Positron emission tomography
[C]Doxepin
[C]Pyrilamine

Access to Document

10.1016/0304-3940(90)90244-4

Cite this

@article{f71905f537544eb5a4f294bc0ad4ada1,

title = "Visualization of histamine H1 receptors in dog brain by positron emission tomography",

abstract = "Histamine H1 receptors were visualized in the living dog brain using [11C]pyrilamine or [11C]doxepin by positron emission tomography (PET). The regional distribution of these carbon-11 labeled compounds in the brain corresponded well with that of the histamine H1 receptors separately determined by in vitro binding assay. The radioactivity in the brain was reduced by treatment with triprolidine (1 mg/kg), a histamine H1 antagonist. The results of our study indicate that it is feasible to visualize histamine H1 receptors in human brain using these 11C-labeled compounds and PET.",

keywords = "Dog, Histamine, Histamine H receptor, In vivo study, Positron emission tomography, [C]Doxepin, [C]Pyrilamine",

author = "Kazuhiko Yanai and Takehiko Watanabe and Jun Hatazawa and Masatoshi Itoh and Kazuo Nunoki and Kentaro Hatano and Ren Iwata and Kiichi Ishiwata and Tatsuo Ido and Taiju Matsuzawa",

note = "Funding Information: The authors thank Mr. Y. Ishikawa, Mr. S. Name-kawa, Mr. S. Seo, and Mr. S. Watanuki for their technical assistance. This work was supported in part by Grant-in-Aid for Specifically Promoted Research 63065004 from the Ministry of Education, Science and Culture of Japan.",

year = "1990",

month = oct,

day = "2",

doi = "10.1016/0304-3940(90)90244-4",

language = "English",

volume = "118",

pages = "41--44",

journal = "Neuroscience Letters",

issn = "0304-3940",

publisher = "Elsevier Ireland Ltd",

number = "1",

}

TY - JOUR

T1 - Visualization of histamine H1 receptors in dog brain by positron emission tomography

AU - Yanai, Kazuhiko

AU - Watanabe, Takehiko

AU - Hatazawa, Jun

AU - Itoh, Masatoshi

AU - Nunoki, Kazuo

AU - Hatano, Kentaro

AU - Iwata, Ren

AU - Ishiwata, Kiichi

AU - Ido, Tatsuo

AU - Matsuzawa, Taiju

N1 - Funding Information: The authors thank Mr. Y. Ishikawa, Mr. S. Name-kawa, Mr. S. Seo, and Mr. S. Watanuki for their technical assistance. This work was supported in part by Grant-in-Aid for Specifically Promoted Research 63065004 from the Ministry of Education, Science and Culture of Japan.

PY - 1990/10/2

Y1 - 1990/10/2

N2 - Histamine H1 receptors were visualized in the living dog brain using [11C]pyrilamine or [11C]doxepin by positron emission tomography (PET). The regional distribution of these carbon-11 labeled compounds in the brain corresponded well with that of the histamine H1 receptors separately determined by in vitro binding assay. The radioactivity in the brain was reduced by treatment with triprolidine (1 mg/kg), a histamine H1 antagonist. The results of our study indicate that it is feasible to visualize histamine H1 receptors in human brain using these 11C-labeled compounds and PET.

AB - Histamine H1 receptors were visualized in the living dog brain using [11C]pyrilamine or [11C]doxepin by positron emission tomography (PET). The regional distribution of these carbon-11 labeled compounds in the brain corresponded well with that of the histamine H1 receptors separately determined by in vitro binding assay. The radioactivity in the brain was reduced by treatment with triprolidine (1 mg/kg), a histamine H1 antagonist. The results of our study indicate that it is feasible to visualize histamine H1 receptors in human brain using these 11C-labeled compounds and PET.

KW - Dog

KW - Histamine

KW - Histamine H receptor

KW - In vivo study

KW - Positron emission tomography

KW - [C]Doxepin

KW - [C]Pyrilamine

UR - http://www.scopus.com/inward/record.url?scp=0025197311&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0025197311&partnerID=8YFLogxK

U2 - 10.1016/0304-3940(90)90244-4

DO - 10.1016/0304-3940(90)90244-4

M3 - Article

C2 - 2259465

AN - SCOPUS:0025197311

SN - 0304-3940

VL - 118

SP - 41

EP - 44

JO - Neuroscience Letters

JF - Neuroscience Letters

IS - 1

ER -

Visualization of histamine H₁ receptors in dog brain by positron emission tomography

Abstract

Keywords

Access to Document

Other files and links

Fingerprint

Cite this