Visualization of murine lymph vessels using photoacoustic imaging with contrast agents

Ryo Nagaoka; Takuya Tabata; Shin Yoshizawa; Shin ichiro Umemura; Yoshifumi Saijo

doi:10.1016/j.pacs.2018.01.001

Visualization of murine lymph vessels using photoacoustic imaging with contrast agents

Ryo Nagaoka, Takuya Tabata, Shin Yoshizawa, Shin ichiro Umemura, Yoshifumi Saijo

Tohoku University

Research output: Contribution to journal › Article › peer-review

18 Citations (Scopus)

Abstract

Metastasis frequently occurs even in the early stage of breast cancer. This research studied the feasibility of using photoacoustic (PA) imaging for identifying metastasis in the lymph vessels of mice. The photoacoustic efficiency of various contrast agents was investigated, and the influence of scattered light was evaluated by using a lymph vessel phantom. The lymph vessels of mice were then visualized using the selected contrast agents: indocyanine green (ICG) and gold nanorods (AuNR). The attenuation of the PA imaging was −1.90 dB/mm, whereas that of the fluorescence imaging was −4.45 dB/mm. The results indicate the potential of identifying sentinel lymph nodes by using PA imaging with these contrast agents.

Original language	English
Pages (from-to)	39-48
Number of pages	10
Journal	Photoacoustics
Volume	9
DOIs	https://doi.org/10.1016/j.pacs.2018.01.001
Publication status	Published - 2018 Mar

Keywords

3D-real-time imaging systems
Contrast agents
Light wavelength dependence of photoacoustic signals
Lymph vessels
Photoacoustic tomography
Ultrasonic transducer arrays

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1016/j.pacs.2018.01.001

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title = "Visualization of murine lymph vessels using photoacoustic imaging with contrast agents",

abstract = "Metastasis frequently occurs even in the early stage of breast cancer. This research studied the feasibility of using photoacoustic (PA) imaging for identifying metastasis in the lymph vessels of mice. The photoacoustic efficiency of various contrast agents was investigated, and the influence of scattered light was evaluated by using a lymph vessel phantom. The lymph vessels of mice were then visualized using the selected contrast agents: indocyanine green (ICG) and gold nanorods (AuNR). The attenuation of the PA imaging was −1.90 dB/mm, whereas that of the fluorescence imaging was −4.45 dB/mm. The results indicate the potential of identifying sentinel lymph nodes by using PA imaging with these contrast agents.",

keywords = "3D-real-time imaging systems, Contrast agents, Light wavelength dependence of photoacoustic signals, Lymph vessels, Photoacoustic tomography, Ultrasonic transducer arrays",

author = "Ryo Nagaoka and Takuya Tabata and Shin Yoshizawa and Umemura, {Shin ichiro} and Yoshifumi Saijo",

note = "Funding Information: This work was funded by the ImPACT Program of the Council for Science, Technology and Innovation (Cabinet Office, Government of Japan) . This work was supported a JSPS Grant-in-Aid for Young Scientists (Start-up) 16H066190 . Publisher Copyright: {\textcopyright} 2018 The Authors",

year = "2018",

month = mar,

doi = "10.1016/j.pacs.2018.01.001",

language = "English",

volume = "9",

pages = "39--48",

journal = "Photoacoustics",

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T1 - Visualization of murine lymph vessels using photoacoustic imaging with contrast agents

AU - Nagaoka, Ryo

AU - Tabata, Takuya

AU - Yoshizawa, Shin

AU - Umemura, Shin ichiro

AU - Saijo, Yoshifumi

N1 - Funding Information: This work was funded by the ImPACT Program of the Council for Science, Technology and Innovation (Cabinet Office, Government of Japan) . This work was supported a JSPS Grant-in-Aid for Young Scientists (Start-up) 16H066190 . Publisher Copyright: © 2018 The Authors

PY - 2018/3

Y1 - 2018/3

N2 - Metastasis frequently occurs even in the early stage of breast cancer. This research studied the feasibility of using photoacoustic (PA) imaging for identifying metastasis in the lymph vessels of mice. The photoacoustic efficiency of various contrast agents was investigated, and the influence of scattered light was evaluated by using a lymph vessel phantom. The lymph vessels of mice were then visualized using the selected contrast agents: indocyanine green (ICG) and gold nanorods (AuNR). The attenuation of the PA imaging was −1.90 dB/mm, whereas that of the fluorescence imaging was −4.45 dB/mm. The results indicate the potential of identifying sentinel lymph nodes by using PA imaging with these contrast agents.

AB - Metastasis frequently occurs even in the early stage of breast cancer. This research studied the feasibility of using photoacoustic (PA) imaging for identifying metastasis in the lymph vessels of mice. The photoacoustic efficiency of various contrast agents was investigated, and the influence of scattered light was evaluated by using a lymph vessel phantom. The lymph vessels of mice were then visualized using the selected contrast agents: indocyanine green (ICG) and gold nanorods (AuNR). The attenuation of the PA imaging was −1.90 dB/mm, whereas that of the fluorescence imaging was −4.45 dB/mm. The results indicate the potential of identifying sentinel lymph nodes by using PA imaging with these contrast agents.

KW - 3D-real-time imaging systems

KW - Contrast agents

KW - Light wavelength dependence of photoacoustic signals

KW - Lymph vessels

KW - Photoacoustic tomography

KW - Ultrasonic transducer arrays

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SP - 39

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JO - Photoacoustics

JF - Photoacoustics

ER -

Visualization of murine lymph vessels using photoacoustic imaging with contrast agents

Abstract

Keywords

UN SDGs

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