Vitamin K suppresses lipopolysaccharide-induced inflammation in the rat

Yusuke Ohsaki, Hitoshi Shirakawa, Kazuyuki Hiwatashi, Yuji Furukawa, Takeo Mizutani, Michio Komai

Research output: Contribution to journalArticlepeer-review

143 Citations (Scopus)


Vitamin K (K) is essential for blood coagulation and bone metabolism in mammals. K acts as a cofactor in the posttranslational synthesis of γ-carboxyglutamic acid from glutamic acid residues. In addition to the liver and bone, K is found in the brain, heart, kidney and gonadal tissue. However, the physiological role of K in these various organs is not yet fully understood. It is likely that K has functions other than its role as a cofactor of protein γ-glutamyl carboxylation. We used in this study the DNA microarray technique to identify the effect of K status on gene expression in the rat liver. The expression of genes involved in the acute inflammation response was enhanced in rats fed with a K-deficient diet relative to the control and K1-supplemented diet groups. Moreover, dietary supplementation with K1 suppressed the inflammation induced by lipopolysaccharide administration. These results indicate that orally administrated K1 suppressed inflammation in the rat.

Original languageEnglish
Pages (from-to)926-932
Number of pages7
JournalBioscience, Biotechnology and Biochemistry
Issue number4
Publication statusPublished - 2006


  • DNA microarray
  • Inflammation
  • Interleukin-6
  • Vitamin K


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