Water soluble nucleic acid analogs: Preparation and properties

In order to prepare water soluble natural and synthetic polymers, which contain nucleic acid base units as the functional side groups, a different sort of polymers, such as poly(ethyleneimine), poly-(amino acids) and so on were used as the base materials. The properties of the polymers derived, in particular the specific interaction between nucleic acid base containing complementary polymers was studied in detail. Introduction of the base units onto hyaluronic acid was also carried out. Applicabilities of these polymers obtained, for example as the controlled release system by using reversible photodimerization reaction of thymine bases were also shown.