Whole brain and grey matter volume of Japanese patients with multiple sclerosis

Tetsuya Akaishi; Ichiro Nakashima; Shunji Mugikura; Masashi Aoki; Kazuo Fujihara

doi:10.1016/j.jneuroim.2017.03.009

Whole brain and grey matter volume of Japanese patients with multiple sclerosis

Tetsuya Akaishi, Ichiro Nakashima, Shunji Mugikura, Masashi Aoki, Kazuo Fujihara

Research output: Contribution to journal › Article › peer-review

22 Citations (Scopus)

Abstract

We evaluated the brain volume and rate of atrophy in 85 Japanese patients with multiple sclerosis (MS). The mean brain volume was smaller and the rate of atrophy appeared to be more rapid in MS patients than in normal subjects. The brain atrophy seemed to exist from the early stage of MS and was prominent in the grey matter. Patients with progressive MS showed severer atrophy. We show the existence of pathological brain atrophy in Japanese MS patients for the first time, although the rate of atrophy may be much slower than in Caucasian patients.

Original language	English
Pages (from-to)	68-75
Number of pages	8
Journal	Journal of Neuroimmunology
Volume	306
DOIs	https://doi.org/10.1016/j.jneuroim.2017.03.009
Publication status	Published - 2017 May 15

Keywords

Brain atrophy
Grey matter volume
Japanese
Multiple sclerosis
Whole brain volume

Access to Document

10.1016/j.jneuroim.2017.03.009

Cite this

@article{473968592d36441a86841b9668faf3fe,

title = "Whole brain and grey matter volume of Japanese patients with multiple sclerosis",

abstract = "We evaluated the brain volume and rate of atrophy in 85 Japanese patients with multiple sclerosis (MS). The mean brain volume was smaller and the rate of atrophy appeared to be more rapid in MS patients than in normal subjects. The brain atrophy seemed to exist from the early stage of MS and was prominent in the grey matter. Patients with progressive MS showed severer atrophy. We show the existence of pathological brain atrophy in Japanese MS patients for the first time, although the rate of atrophy may be much slower than in Caucasian patients.",

keywords = "Brain atrophy, Grey matter volume, Japanese, Multiple sclerosis, Whole brain volume",

author = "Tetsuya Akaishi and Ichiro Nakashima and Shunji Mugikura and Masashi Aoki and Kazuo Fujihara",

note = "Publisher Copyright: {\textcopyright} 2017 Elsevier B.V.",

year = "2017",

month = may,

day = "15",

doi = "10.1016/j.jneuroim.2017.03.009",

language = "English",

volume = "306",

pages = "68--75",

journal = "Journal of Neuroimmunology",

issn = "0165-5728",

publisher = "Elsevier",

}

TY - JOUR

T1 - Whole brain and grey matter volume of Japanese patients with multiple sclerosis

AU - Akaishi, Tetsuya

AU - Nakashima, Ichiro

AU - Mugikura, Shunji

AU - Aoki, Masashi

AU - Fujihara, Kazuo

PY - 2017/5/15

Y1 - 2017/5/15

N2 - We evaluated the brain volume and rate of atrophy in 85 Japanese patients with multiple sclerosis (MS). The mean brain volume was smaller and the rate of atrophy appeared to be more rapid in MS patients than in normal subjects. The brain atrophy seemed to exist from the early stage of MS and was prominent in the grey matter. Patients with progressive MS showed severer atrophy. We show the existence of pathological brain atrophy in Japanese MS patients for the first time, although the rate of atrophy may be much slower than in Caucasian patients.

AB - We evaluated the brain volume and rate of atrophy in 85 Japanese patients with multiple sclerosis (MS). The mean brain volume was smaller and the rate of atrophy appeared to be more rapid in MS patients than in normal subjects. The brain atrophy seemed to exist from the early stage of MS and was prominent in the grey matter. Patients with progressive MS showed severer atrophy. We show the existence of pathological brain atrophy in Japanese MS patients for the first time, although the rate of atrophy may be much slower than in Caucasian patients.

KW - Brain atrophy

KW - Grey matter volume

KW - Japanese

KW - Multiple sclerosis

KW - Whole brain volume

UR - http://www.scopus.com/inward/record.url?scp=85015804121&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85015804121&partnerID=8YFLogxK

U2 - 10.1016/j.jneuroim.2017.03.009

DO - 10.1016/j.jneuroim.2017.03.009

M3 - Article

C2 - 28385190

AN - SCOPUS:85015804121

SN - 0165-5728

VL - 306

SP - 68

EP - 75

JO - Journal of Neuroimmunology

JF - Journal of Neuroimmunology

ER -

Whole brain and grey matter volume of Japanese patients with multiple sclerosis

Abstract

Keywords

Access to Document

Other files and links

Fingerprint

Cite this