Abstract
The Wnt family of secreted signaling molecules is essential in embryo development and tumor formation. In addition to the Frizzled family of serpentine receptors, LRP5, a member of the LDL receptor family, was recently shown to function as Wnt receptor. The finding of unique mutations in the human LRP5 gene as a modulator of bone mass establishes the importance of this novel and unexpected role of Wnt/LRP5 signaling in bone development and bone metabolism.
| Original language | English |
|---|---|
| Pages (from-to) | 813-818 |
| Number of pages | 6 |
| Journal | Clinical calcium |
| Volume | 15 |
| Issue number | 5 |
| Publication status | Published - 2005 May |