Wnt signaling and bone metabolism

Hiroshi Asaba, Juro Sakai

Research output: Contribution to journalArticlepeer-review

1 Citation (Scopus)


The Wnt family of secreted signaling molecules is essential in embryo development and tumor formation. In addition to the Frizzled family of serpentine receptors, LRP5, a member of the LDL receptor family, was recently shown to function as Wnt receptor. The finding of unique mutations in the human LRP5 gene as a modulator of bone mass establishes the importance of this novel and unexpected role of Wnt/LRP5 signaling in bone development and bone metabolism.

Original languageEnglish
Pages (from-to)813-818
Number of pages6
JournalClinical calcium
Issue number5
Publication statusPublished - 2005 May


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