X-ray imaging of newly-developed gadolinium compound/silica core-shell particles

Hikaru Morimoto, Marie Minato, Tomohiko Nakagawa, Masahide Sato, Yoshio Kobayashi, Kohsuke Gonda, Motohiro Takeda, Noriaki Ohuchi, Noboru Suzuki

Research output: Contribution to journalArticlepeer-review

9 Citations (Scopus)


A preparation method for gadolinium compound (Gd) nanoparticles coated with silica (Gd/SiO2) is proposed. Gd nanoparticles were prepared with a homogeneous precipitation method at 80 °C using 1.0 × 10-3 M Gd(NO3)3 and 0.5 M urea in the presence of 1.0 g/L stabilizer. Among stabilizers examined. Sodium n-dodecyl sulfate (SDS) was suitable as the stabilizer for preparing small Gd nanoparticles, and consequently Gd nanoparticles with a size of 46.2 ± 12.4 nm were prepared using the SDS. Silica-coating of the Gd nanoparticles was performed by a Stöber method at room temperature using 0.013 M TEOS and 2.0 × 10-3 M NaOH in water/1-propanol solution in the presence of 1.0 × 10-3 M Gd nanoparticles, which resulted in production of Gd/SiO2 particles with an average size of 64.2 ± 14.4 nm. The Gd/SiO2 particles were surface-modified with 3-aminopropyltrimethoxysilane and succinic anhydride. It was confirmed by measurement of electrophretic light scattering that amino group or carboxyl group was introduced onto the Gd/SiO2 particles. The gadolinium concentration of 1.0 × 10-3 M in the as-prepared colloid solution was increased up to a gadolinium concentration of 0.4 M by centrifugation. The core-shell structure of Gd/SiO2 particles was undamaged, and the colloid solution was still colloidally stable, even after the concentrating process. The concentrated Gd/SiO2 colloid solution showed an X-ray image with contrast as high as a commercial Gd complex contrast agent. Internal organs in a mouse could be imaged injecting the concentrated colloid solution into it.

Original languageEnglish
Pages (from-to)650-657
Number of pages8
JournalJournal of Sol-Gel Science and Technology
Issue number3
Publication statusPublished - 2011 Sept


  • Core-shell
  • Gadolinium
  • Homogeneous precipitation method
  • Particle
  • Silica
  • X-ray imaging


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