Zeta potential of alumina powders with different crystalline phases in simulated body fluids

Masakazu Kawashita, Ayumi Kamitani, Toshiki Miyazaki, Naoko Matsui, Zhixia Li, Hiroyasu Kanetaka, Masami Hashimoto

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15 Citations (Scopus)


The zeta potential of alumina (Al 2O 3) powder with different crystalline phases, prepared by heat treatment of boehmite, was measured in simulated body fluids in order to discuss the mechanism on in vivo formation of a calcium and phosphorus (CaP)-rich layer on bone cement containing δ-Al 2O 3-based bead powder. γ, δ, and θ-Al 2O 3 powders were obtained by heat treatment of boehmite powder at 600 °C, 900 °C, and 1025 °C, respectively. It was found that δ-Al 2O 3 gave a negative zeta potential in an acidic simulated body fluid, whereas γ-Al 2O 3 and θ-Al 2O 3 gave a positive potentials. During the bone fracture healing process, acidic conditions are maintained at the site of fracture for several days. Consequently, it is speculated that the negative surface potential of δ-Al 2O 3 in an acidic body fluid, similar to the fracture site, might be responsible for the in vivo formation of the CaP-rich layer on the overlying bone cement, given that the negatively charged surface of δ-Al 2O 3 would attract calcium ions from the surrounding body fluid, thereby facilitating the formation of the CaP-rich layer.

Original languageEnglish
Pages (from-to)2617-2622
Number of pages6
JournalMaterials Science and Engineering C
Issue number8
Publication statusPublished - 2012 Dec 1


  • Alumina
  • Calcium phosphate
  • Simulated body fluid
  • Zeta potential


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