α-FP normalization as a prognostic factor for mediastinal origin embryonal carcinoma: Report of five cases

Yasuko Murakawa; Nobuaki Satake; Syunsuke Kato; Takasi Yosioka; Ryunosuke Kanamaru

doi:10.2169/internalmedicine.41.883

α-FP normalization as a prognostic factor for mediastinal origin embryonal carcinoma: Report of five cases

Yasuko Murakawa, Nobuaki Satake, Syunsuke Kato, Takasi Yosioka, Ryunosuke Kanamaru

Institute of Development, Aging and Cancer (IDAC)

Research output: Contribution to journal › Article › peer-review

2 Citations (Scopus)

Abstract

It is well known that a subgroup of germ cell tumors, embryonal carcinoma of extra-gonadal origin have a poor prognosis. We have encountered five cases of mediastinal embryonal carcinoma treated with high-dose chemotherapy (HD-CT) supported by auto-PBSCT in four, and resection in three. Our cases indicated that normalization of the α-FP tumor marker level during standard chemotherapy is a very important factor for cure, and the resection of the residual mass after chemotherapy is indicated due to the great risk of remnant malignant cells despite HD-CT.

Original language	English
Pages (from-to)	883-888
Number of pages	6
Journal	Internal Medicine
Volume	41
Issue number	10
DOIs	https://doi.org/10.2169/internalmedicine.41.883
Publication status	Published - 2002 Oct 1

Keywords

Germ cell tumors (GCTs)
High-dose chemotherapy (HD-CT) supported by auto-PBSCT

ASJC Scopus subject areas

Internal Medicine

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10.2169/internalmedicine.41.883

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abstract = "It is well known that a subgroup of germ cell tumors, embryonal carcinoma of extra-gonadal origin have a poor prognosis. We have encountered five cases of mediastinal embryonal carcinoma treated with high-dose chemotherapy (HD-CT) supported by auto-PBSCT in four, and resection in three. Our cases indicated that normalization of the α-FP tumor marker level during standard chemotherapy is a very important factor for cure, and the resection of the residual mass after chemotherapy is indicated due to the great risk of remnant malignant cells despite HD-CT.",

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AU - Murakawa, Yasuko

AU - Satake, Nobuaki

AU - Kato, Syunsuke

AU - Yosioka, Takasi

AU - Kanamaru, Ryunosuke

PY - 2002/10/1

Y1 - 2002/10/1

N2 - It is well known that a subgroup of germ cell tumors, embryonal carcinoma of extra-gonadal origin have a poor prognosis. We have encountered five cases of mediastinal embryonal carcinoma treated with high-dose chemotherapy (HD-CT) supported by auto-PBSCT in four, and resection in three. Our cases indicated that normalization of the α-FP tumor marker level during standard chemotherapy is a very important factor for cure, and the resection of the residual mass after chemotherapy is indicated due to the great risk of remnant malignant cells despite HD-CT.

AB - It is well known that a subgroup of germ cell tumors, embryonal carcinoma of extra-gonadal origin have a poor prognosis. We have encountered five cases of mediastinal embryonal carcinoma treated with high-dose chemotherapy (HD-CT) supported by auto-PBSCT in four, and resection in three. Our cases indicated that normalization of the α-FP tumor marker level during standard chemotherapy is a very important factor for cure, and the resection of the residual mass after chemotherapy is indicated due to the great risk of remnant malignant cells despite HD-CT.

KW - Germ cell tumors (GCTs)

KW - High-dose chemotherapy (HD-CT) supported by auto-PBSCT

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α-FP normalization as a prognostic factor for mediastinal origin embryonal carcinoma: Report of five cases

Abstract

Keywords

ASJC Scopus subject areas

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