Key features of the β-isocupreidine (β-ICD)-catalyzed asymmetric Baylis-Hillman reaction of aldehydes with 1,1,1,3,3,3-hexafluoroisopropyl acrylate (HFIPA) are presented. In addition, an improved method using azeotropically dried β-ICD is described.
|Number of pages||9|
|Publication status||Published - 2006 Jan 9|
- 1,1,1,3,3,3-Hexafluoroisopropyl acrylate
- Organic catalysis
ASJC Scopus subject areas
- Drug Discovery
- Organic Chemistry