検索結果
2011
Qiu, C. S. ,
Wyhe, L. L. V. ,
Sasaki, M. ,
Sakai, R. ,
Swanson, G. T. &
Gereau IV, R. W. ,
2011 5月 ,
In: Pain. 152 ,
5 ,
p. 1052-1060 9 p. 研究成果: Article › 査読
Antagonist
100%
Hypersensitivity
60%
Anodyne
60%
Formaldehyde
40%
Receptor
40%
Terpenoid
100%
Radical Cyclization
66%
Cyclization Reaction
66%
Ring Formation
66%
Assay
66%
Unno, M. ,
Shinohara, M. ,
Takayama, K. ,
Tanaka, H. ,
Teruya, K. ,
Doh-Ura, K. ,
Sakai, R. ,
Sasaki, M. &
Ikeda-Saito, M. ,
2011 10月 28 ,
In: Journal of Molecular Biology. 413 ,
3 ,
p. 667-683 17 p. 研究成果: Article › 査読
Agonist
100%
Ligand Binding
100%
Kainate Receptor
100%
Crystal Structure
50%
Conformation
50%
Thioester
100%
Tetrahydropyran
100%
Cyclization Reaction
66%
Biosynthesis
33%
Diastereoselectivity
33%
Cagide, E. ,
Louzao, M. C. ,
Espiña, B. ,
Ares, I. R. ,
Vieytes, M. R. ,
Sasaki, M. ,
Fuwa, H. ,
Tsukano, C. ,
Konno, Y. ,
Yotsu-Yamashita, M. ,
Paquette, L. A. ,
Yasumoto, T. &
Botana, L. M. ,
2011 6月 20 ,
In: Chemical Research in Toxicology. 24 ,
6 ,
p. 835-842 8 p. 研究成果: Article › 査読
Toxin
100%
Cytotoxicity
80%
Neuroblastoma
80%
Ciguatoxin
60%
Calcium
60%
Polycyclic Ether
100%
Occurrence in Nature
50%
Application
50%
Total Synthesis
50%
Phosphate
25%
Tsubone, K. ,
Hashizume, K. ,
Fuwa, H. &
Sasaki, M. ,
2011 1月 26 ,
In: Tetrahedron Letters. 52 ,
4 ,
p. 548-551 4 p. 研究成果: Article › 査読
Synthesis (Chemical)
100%
Acid
66%
Chloride
33%
Polycyclic Ether
33%
Antifungal
33%
Tsubone, K. ,
Hashizume, K. ,
Fuwa, H. &
Sasaki, M. ,
2011 9月 2 ,
In: Tetrahedron. 67 ,
35 ,
p. 6600-6615 16 p. 研究成果: Article › 査読
Synthesis (Chemical)
100%
Polycyclic Ether
66%
Antifungal
66%
Acid
66%
Polyether
33%
Sonoshita, M. ,
Aoki, M. ,
Fuwa, H. ,
Aoki, K. ,
Hosogi, H. ,
Sakai, Y. ,
Hashida, H. ,
Takabayashi, A. ,
Sasaki, M. ,
Robine, S. ,
Itoh, K. ,
Yoshioka, K. ,
Kakizaki, F. ,
Kitamura, T. ,
Oshima, M. &
Taketo, M. M. ,
2011 1月 18 ,
In: Cancer Cell. 19 ,
1 ,
p. 125-137 13 p. 研究成果: Article › 査読
Notch Signaling
100%
Notch Signaling Pathway
100%
Metastatic Carcinoma
60%
Colon
60%
Metastasis
60%
Synthesis (Chemical)
100%
Reaction Yield
25%
Cross-Coupling Reaction
25%
Structure-Activity Relationship
25%
Marine Natural Products
25%
Thioester
100%
Cross-Coupling Reaction
50%
Macrolide Antibiotic Agent
50%
Polyether
50%
Palladium
50%
Fuwa, H. ,
Suzuki, T. ,
Kubo, H. ,
Yamori, T. &
Sasaki, M. ,
2011 2月 25 ,
In: Chemistry - A European Journal. 17 ,
9 ,
p. 2678-2688 11 p. 研究成果: Article › 査読
Total Synthesis
100%
Tetrahydropyran
66%
Antiproliferative
33%
Enantiomer
33%
Alkene
33%
Polycyclic Ether
100%
Polyether
100%
Synthesis (Chemical)
100%
Total Synthesis
100%
Phosphate
50%
2010
Total Synthesis
100%
Antiproliferative
50%
Alkene
50%
Macrolide Antibiotic Agent
50%
Metathesis Reaction
50%
Fuwa, H. ,
Matsukida, S. &
Sasaki, M. ,
2010 5月 14 ,
In: Synlett. 8 ,
p. 1239-1242 4 p. , U01010ST.
研究成果: Article › 査読
Ester
100%
Synthesis (Chemical)
100%
Alkyne
50%
Cyclization Reaction
50%
Pyran
50%
Fuwa, H. ,
Yamaguchi, H. &
Sasaki, M. ,
2010 9月 18 ,
In: Tetrahedron. 66 ,
38 ,
p. 7492-7503 12 p. 研究成果: Article › 査読
Total Synthesis
100%
Cyclization Reaction
50%
Yamaguchi Esterification
50%
Conjugate
50%
Gill, M. B. ,
Frausto, S. ,
Ikoma, M. ,
Sasaki, M. ,
Oikawa, M. ,
Sakai, R. &
Swanson, G. T. ,
2010 7月 ,
In: British Journal of Pharmacology. 160 ,
6 ,
p. 1417-1429 13 p. 研究成果: Article › 査読
Receptor
100%
Antagonist
50%
Glutamic Acid
50%
Hydroxyl Group
50%
Propionic Acid
50%
Total Synthesis
100%
Alkene
50%
Cyclization Reaction
50%
Chemoselectivity
50%
Tetrahydropyran
50%
Alonso, E. ,
Vale, C. ,
Sasaki, M. ,
Fuwa, H. ,
Konno, Y. ,
Perez, S. ,
Vieytes, M. R. &
Botana, L. M. ,
2010 5月 15 ,
In: Journal of Cellular Biochemistry. 110 ,
2 ,
p. 497-508 12 p. 研究成果: Article › 査読
Oscillation
100%
Electric Potential
50%
Potassium Channel
50%
Membrane Potential
50%
Granule Cell
50%
Synthesis (Chemical)
100%
Phosphate
50%
Cyclization Reaction
50%
Enol Ether
50%
Enol
50%
Ebine, M. ,
Suga, Y. ,
Fuwa, H. &
Sasaki, M. ,
2010 ,
In: Organic and Biomolecular Chemistry. 8 ,
1 ,
p. 39-42 4 p. 研究成果: Article › 査読
Diol
100%
Reaction Yield
100%
Synthesis (Chemical)
100%
Amount
100%
Total Synthesis
100%
Oikawa, M. ,
Ikoma, M. ,
Sasaki, M. ,
Gill, M. B. ,
Swanson, G. T. ,
Shimamoto, K. &
Sakai, R. ,
2010 6月 1 ,
In: Bioorganic and Medicinal Chemistry. 18 ,
11 ,
p. 3795-3804 10 p. 研究成果: Article › 査読
Glutamate
100%
Synthesis (Chemical)
57%
Synthesis
57%
Diels-Alder Reaction
14%
Imidate
14%
Leanne Lash-Van Wyhe, L. ,
Postila, P. A. ,
Tsubone, K. ,
Sasaki, M. ,
Pentikäinen, O. T. ,
Sakai, R. &
Swanson, G. T. ,
2010 3月 ,
In: Neuropharmacology. 58 ,
3 ,
p. 640-649 10 p. 研究成果: Article › 査読
Kainate Receptor
100%
Kainic Acid Receptor
80%
Pharmacological Activity
40%
Marine Toxin
40%
Receptor Subunit
40%
Alkene
100%
Stereoselective Synthesis
100%
Cyclization Reaction
100%
Tetrahydropyran
100%
Cross Metathesis
50%
Synthesis (Chemical)
100%
Acid
100%
Ciguatoxin
50%
Polycyclic Ether
50%
Antifungal
50%
Schlumberger, S. ,
Ouanounou, G. ,
Girard, E. ,
Sasaki, M. ,
Fuwa, H. ,
Louzao, M. C. ,
Botana, L. M. ,
Benoit, E. &
Molgó, J. ,
2010 10月 ,
In: Toxicon. 56 ,
5 ,
p. 785-791 7 p. 研究成果: Article › 査読
Action Potential
100%
Muscle Twitch
100%
Tension
100%
Skeletal Muscle
66%
Xenopus
66%
Total Synthesis
100%
Tetrahydropyran
66%
Enantiomer
33%
Alkene
33%
Cross Metathesis
33%
2009
Metathesis
100%
Amide
33%
Reaction Yield
33%
Diels-Alder Reaction
33%
Allylation
33%
Frydenvang, K. ,
Lash, L. L. ,
Naur, P. ,
Postila, P. A. ,
Pickering, D. S. ,
Smith, C. M. ,
Gajhede, M. ,
Sasaki, M. ,
Sakai, R. ,
Pentikänen, O. T. ,
Swanson, G. T. &
Kastrup, J. S. ,
2009 5月 22 ,
In: Journal of Biological Chemistry. 284 ,
21 ,
p. 14219-14229 11 p. 研究成果: Article › 査読
Agonist
100%
Glutamate
60%
Ligand Binding
40%
Kainate Receptor
40%
EC50
40%
Sala, G. L. ,
Ronzitti, G. ,
Sasaki, M. ,
Fuwa, H. ,
Yasumoto, T. ,
Bigiani, A. &
Rossini, G. P. ,
2009 6月 15 ,
In: Chemical Research in Toxicology. 22 ,
6 ,
p. 1077-1085 9 p. 研究成果: Article › 査読
Isoform
100%
Protein
100%
Lysozyme
66%
Myosin
66%
Proteomics
66%
Oikawa, M. ,
Ikoma, M. ,
Sasaki, M. ,
Gill, M. B. ,
Swanson, G. T. ,
Shimamoto, K. &
Sakai, R. ,
2009 ,
In: European Journal of Organic Chemistry. 32 ,
p. 5531-5548 18 p. 研究成果: Article › 査読
Glutamate
100%
Electron Particle
66%
Metathesis
66%
Metathesis Reaction
66%
Cross Metathesis
66%
Phosphate
100%
Cyclization Reaction
100%
Indoline
100%
Enol
100%
Synthesis (Chemical)
100%
Synthesis (Chemical)
100%
Procedure
20%
Fuwa, H. ,
Ishigai, K. ,
Goto, T. ,
Suzuki, A. &
Sasaki, M. ,
2009 6月 5 ,
In: Journal of Organic Chemistry. 74 ,
11 ,
p. 4024-4040 17 p. 研究成果: Article › 査読
Acid
100%
Polycyclic Ether
66%
Absolute Configuration
66%
Occurrence in Nature
66%
Synthesis (Chemical)
66%
Fuwa, H. ,
Saito, A. ,
Naito, S. ,
Konoki, K. ,
Yotsu-Yamashita, M. &
Sasaki, M. ,
2009 11月 23 ,
In: Chemistry - A European Journal. 15 ,
46 ,
p. 12807-12818 12 p. 研究成果: Article › 査読
Total Synthesis
100%
Ring Closing Metathesis
66%
Structure
66%
Antiproliferative
33%
Phosphate
33%
Synthesis (Chemical)
100%
Macrolide Antibiotic Agent
66%
Polyether
66%
Palladium
33%
Occurrence in Nature
33%
2008
Synthesis (Chemical)
100%
Enol Ether
50%
Ring Closing Metathesis
25%
Marine Metabolite
25%
Application
25%
Fuwa, H. ,
Tako, T. ,
Ebine, M. &
Sasaki, M. ,
2008 9月 5 ,
In: Chemistry Letters. 37 ,
9 ,
p. 904-905 2 p. 研究成果: Article › 査読
Procedure
100%
Quinodimethane
66%
Indole
66%
Palladium
33%
Takeda, Y. ,
Shi, J. ,
Oikawa, M. &
Sasaki, M. ,
2008 3月 6 ,
In: Organic letters. 10 ,
5 ,
p. 1013-1016 4 p. 研究成果: Article › 査読
Absolute Configuration
100%
Synthesis (Chemical)
100%
NMR Spectroscopy
100%
Macrolide Antibiotic Agent
50%
Polyether
50%
Lash, L. L. ,
Sanders, J. M. ,
Akiyama, N. ,
Shoji, M. ,
Postila, P. ,
Pentikäinen, O. T. ,
Sasaki, M. ,
Sakai, R. &
Swanson, G. T. ,
2008 2月 ,
In: Journal of Pharmacology and Experimental Therapeutics. 324 ,
2 ,
p. 484-496 13 p. 研究成果: Article › 査読
Kainate Receptor
100%
Kainic Acid Receptor
90%
Antagonist
40%
Selectivity
40%
Convulsant
30%
Sasaki, M. ,
Tsubone, K. ,
Aoki, K. ,
Akiyama, N. ,
Shoji, M. ,
Oikawa, M. ,
Sakai, R. &
Shimamoto, K. ,
2008 1月 4 ,
In: Journal of Organic Chemistry. 73 ,
1 ,
p. 264-273 10 p. 研究成果: Article › 査読
Structure-Activity Relationship
100%
Amino Alcohol
100%
Glutamate
100%
Total Synthesis
100%
Hydrogenation
50%
Ikoma, M. ,
Oikawa, M. ,
Gill, M. B. ,
Swanson, G. T. ,
Sakai, R. ,
Shimamoto, K. &
Sasaki, M. ,
2008 11月 ,
In: European Journal of Organic Chemistry. 31 ,
p. 5215-5220 6 p. 研究成果: Article › 査読
Glutamate
100%
Amide
50%
Bioactivity
50%
Carbonyl Group
50%
Metathesis
50%
Gambieric Acid B
100%
Polycyclic Ether
66%
Absolute Configuration
66%
Synthesis (Chemical)
66%
Diastereomer
33%
Heterocyclic Compound
100%
Diels-Alder Intramolecular Cycloaddition
50%
Metathesis
50%
Metathesis Reaction
50%
Synthesis (Chemical)
50%
Synthesis (Chemical)
100%
Bromide
33%
Boronic Acid
33%
Miyaura Reaction
33%
Alkaloid
33%
Azaspiracid
100%
Group
60%
Synthesis
60%
Shellfish Toxin
40%
Synthesis (Chemical)
40%
Synthesis (Chemical)
100%
Total Synthesis
66%
Phosphate
33%
Alkene
33%
Polycyclic Ether
33%
Fuwa, H. ,
Naito, S. ,
Goto, T. &
Sasaki, M. ,
2008 6月 9 ,
In: Angewandte Chemie - International Edition. 47 ,
25 ,
p. 4737-4739 3 p. 研究成果: Article › 査読
Total Synthesis
100%
Cytotoxicity
50%
Tetrahydropyran
50%
Ring Closing Metathesis
50%
Marine Metabolite
50%
2007
Enol Ether
100%
Procedure
100%
Alkaloid
66%
Synthesis (Chemical)
66%
Total Synthesis
66%
Intramolecular Heck Reaction
100%
Quinodimethane
100%
Diels-Alder Cycloaddition
100%
Indole
100%
Nitrogen
50%