検索結果
2007
Indole
100%
Synthesis (Chemical)
66%
Pyrrole
33%
Point Group C3
33%
Coupling Reaction
33%
Oikawa, M. ,
Takeda, Y. ,
Naito, S. ,
Hashizume, D. ,
Koshino, H. &
Sasaki, M. ,
2007 6月 11 ,
In: Tetrahedron Letters. 48 ,
24 ,
p. 4255-4258 4 p. 研究成果: Article › 査読
Isoquinoline
100%
Aldehyde
66%
Maleimide
66%
Diastereomer
33%
Reaction Yield
33%
Synthesis (Chemical)
100%
Polycyclic Ether
66%
Antifungal
66%
Polyether
66%
Acid
66%
Protein
100%
Peptide
100%
Polycyclic Ether
100%
Melittin
100%
Ether
100%
Polycyclic Ether
100%
Occurrence in Nature
80%
Total Synthesis
60%
Application
40%
Phosphate
20%
Fuwa, H. ,
Takahashi, Y. ,
Konno, Y. ,
Watanabe, N. ,
Miyashita, H. ,
Sasaki, M. ,
Natsugaril, H. ,
Kan, T. ,
Fukuyama, T. ,
Tomita, T. &
Iwatsubo, T. ,
2007 6月 ,
In: ACS Chemical Biology. 2 ,
6 ,
p. 408-418 11 p. 研究成果: Article › 査読
Synthesis
100%
Secretase
100%
Molecular Probe
100%
N-Terminus
33%
Biotin
33%
Coupling Reaction
100%
Ring Closing Metathesis
50%
Allylation
50%
Ugi Condensation
50%
Analytical Method
50%
Stereoselective Synthesis
100%
Aldehyde
50%
Tetrahydrofuran
50%
Gambieric Acid A
50%
Acetylide
50%
Indoline
100%
Indole
100%
Synthesis (Chemical)
66%
Boron Atom
33%
Nucleophile
33%
Polyether
100%
Gambieric Acid A
100%
Esterification
50%
Ring Closing Metathesis
50%
Allylation
50%
Sasaki, M. ,
Akiyama, N. ,
Tsubone, K. ,
Shoji, M. ,
Oikawa, M. &
Sakai, R. ,
2007 8月 6 ,
In: Tetrahedron Letters. 48 ,
32 ,
p. 5697-5700 4 p. 研究成果: Article › 査読
Amino Alcohol
100%
Total Synthesis
100%
Hydrogenation
50%
Ester
50%
Cyclization Reaction
50%
2006
Fuwa, H. ,
Kaneko, A. ,
Sugimoto, Y. ,
Tomita, T. ,
Iwatsubo, T. &
Sasaki, M. ,
2006 12月 31 ,
In: Heterocycles. 70 ,
p. 101-106 6 p. 研究成果: Article › 査読
Phosphate
100%
Ketene
100%
Palladium
100%
Aminal
100%
Synthesis (Chemical)
50%
Sasaki, M. ,
Tsubone, K. ,
Shoji, M. ,
Oikawa, M. ,
Shimamoto, K. &
Sakai, R. ,
2006 11月 15 ,
In: Bioorganic and Medicinal Chemistry Letters. 16 ,
22 ,
p. 5784-5787 4 p. 研究成果: Article › 査読
Glutamate
100%
Probe
100%
Kd
50%
Agonist
50%
Potential
50%
Sanders, J. M. ,
Pentikäinen, O. T. ,
Settimo, L. ,
Pentikäinen, U. ,
Shoji, M. ,
Sasaki, M. ,
Sakai, R. ,
Johnson, M. S. &
Swanson, G. T. ,
2006 ,
In: Molecular pharmacology. 69 ,
6 ,
p. 1849-1860 12 p. 研究成果: Article › 査読
Mutation
100%
Ligand
100%
Dysiherbaine
100%
Kainate Receptor
75%
Kainic Acid Receptor
75%
Ghiaroni, V. ,
Fuwa, H. ,
Inoue, M. ,
Sasaki, M. ,
Miyazaki, K. ,
Hirama, M. ,
Yasumoto, T. ,
Rossini, G. P. ,
Scalera, G. &
Bigiani, A. ,
2006 9月 ,
In: Chemical Senses. 31 ,
7 ,
p. 673-680 8 p. 研究成果: Article › 査読
Ciguatera
100%
Ciguatoxin
80%
Toxin
60%
Toxic Injury
40%
Potassium Channel
40%
Takahashi, Y. ,
Fuwa, H. ,
Kaneko, A. ,
Sasaki, M. ,
Yokoshima, S. ,
Koizumi, H. ,
Takebe, T. ,
Kan, T. ,
Iwatsubo, T. ,
Tomita, T. ,
Natsugari, H. &
Fukuyama, T. ,
2006 7月 15 ,
In: Bioorganic and Medicinal Chemistry Letters. 16 ,
14 ,
p. 3813-3816 4 p. 研究成果: Article › 査読
Inhibitor
100%
Natural Product
100%
Secretase
100%
Aryl Group
50%
Structure-Activity Relationship
50%
Peptidomimetic
100%
Lactam
50%
Alkene
50%
Liquid
50%
Macrocycle
50%
Cytotoxicity
100%
Structure Activity Relationship
100%
Aldehyde
50%
Element
50%
Dinoflagellate
50%
Sasaki, M. ,
Takeda, N. ,
Fuwa, H. ,
Watanabe, R. ,
Satake, M. &
Oshima, Y. ,
2006 8月 7 ,
In: Tetrahedron Letters. 47 ,
32 ,
p. 5687-5691 5 p. 研究成果: Article › 査読
Polycyclic Ether
100%
Synthesis (Chemical)
100%
Red
100%
Prymnesium
100%
Toxin
50%
Oikawa, M. ,
Uehara, T. ,
Iwayama, T. &
Sasaki, M. ,
2006 8月 31 ,
In: Organic letters. 8 ,
18 ,
p. 3943-3946 4 p. 研究成果: Article › 査読
Synthesis (Chemical)
100%
Aldehyde
33%
Epoxide
33%
Pyridine
33%
Stannane
33%
Louzao, M. C. ,
Cagide, E. ,
Vieytes, M. R. ,
Sasaki, M. ,
Fuwa, H. ,
Yasumoto, T. &
Botana, L. M. ,
2006 ,
In: Cellular Physiology and Biochemistry. 17 ,
5-6 ,
p. 257-268 12 p. 研究成果: Article › 査読
Ciguatoxin
100%
Toxin
100%
Neuroblastoma
100%
Sodium Channel
100%
Calcium
100%
Fuwa, H. ,
Ebine, M. ,
Bourdelais, A. J. ,
Baden, D. G. &
Sasaki, M. ,
2006 12月 27 ,
In: Journal of the American Chemical Society. 128 ,
51 ,
p. 16989-16999 11 p. 研究成果: Article › 査読
Occurrence in Nature
100%
Structure
100%
Total Synthesis
60%
Absolute Configuration
40%
Polyether
40%
Shoji, M. ,
Akiyama, N. ,
Tsubone, K. ,
Lash, L. L. ,
Sanders, J. M. ,
Swanson, G. T. ,
Sakai, R. ,
Shimamoto, K. ,
Oikawa, M. &
Sasaki, M. ,
2006 7月 7 ,
In: Journal of Organic Chemistry. 71 ,
14 ,
p. 5208-5220 13 p. 研究成果: Article › 査読
Alkene
100%
Glutamate
100%
Synthesis (Chemical)
100%
Total Synthesis
100%
Point Group C8
100%
Ether
100%
Polycyclic Ether
80%
Structure-Activity Relationship
60%
Structure Activity Relationship
60%
Cytotoxicity
40%
Structure
100%
Synthesis (Chemical)
66%
Total Synthesis
66%
Polycyclic Ether
33%
NMR Data
33%
2005
Molecule
100%
Small Molecule
100%
Solid
66%
Aqueous Solution
33%
Resin
33%
Total Synthesis
100%
Structure-Activity Relationship
66%
Polyether
66%
Synthesis (Chemical)
66%
Hydroxyl Group
33%
Sanders, J. M. ,
Ito, K. ,
Settimo, L. ,
Pentikäinen, O. T. ,
Shoji, M. ,
Sasaki, M. ,
Johnson, M. S. ,
Sakai, R. &
Swanson, G. T. ,
2005 9月 ,
In: Journal of Pharmacology and Experimental Therapeutics. 314 ,
3 ,
p. 1068-1078 11 p. 研究成果: Article › 査読
Selectivity
100%
Dysiherbaine
83%
Kainic Acid Receptor
66%
Agonist
66%
Kainate Receptor
66%
Ghiaroni, V. ,
Sasaki, M. ,
Fuwa, H. ,
Rossini, G. P. ,
Scalera, G. ,
Yasumoto, T. ,
Pietra, P. &
Bigiani, A. ,
2005 5月 ,
In: Toxicological Sciences. 85 ,
1 ,
p. 657-665 9 p. 研究成果: Article › 査読
Taste
100%
Electric Potential
62%
Toxin
50%
Ciguatera
37%
Potassium Current
25%
Chemical Reaction
100%
Diels-Alder Reaction
50%
Soluble
50%
Pool
50%
Resin
25%
Diels-Alder Reaction
100%
Molecule
100%
Chemical Reaction
66%
Organic Synthesis
66%
Alkene
33%
Polycyclic Ether
100%
Antifungal
100%
Cyclic Structure
100%
Synthesis (Chemical)
100%
Acid
100%
Shoji, M. ,
Shiohara, K. ,
Oikawa, M. ,
Sakai, R. &
Sasaki, M. ,
2005 8月 15 ,
In: Tetrahedron Letters. 46 ,
33 ,
p. 5559-5562 4 p. 研究成果: Article › 査読
Synthesis (Chemical)
100%
Glycosylation
33%
Tetrahydrofuran
33%
Ether
33%
Point Group C6
33%
Synthesis (Chemical)
100%
Dioxygen
50%
Polycyclic Ether
50%
Ring Closing Metathesis
50%
Cytotoxic
50%
2004
Molecule
100%
Group
100%
Esterification
33%
Poly(ethylene Glycol)
33%
Reaction Yield
33%
Fuwa, H. ,
Fujikawa, S. ,
Tachibana, K. ,
Takakura, H. &
Sasaki, M. ,
2004 6月 7 ,
In: Tetrahedron Letters. 45 ,
24 ,
p. 4795-4799 5 p. 研究成果: Article › 査読
Fragment
100%
Ciguatoxin
100%
Synthesis (Chemical)
100%
Coupling
50%
Approach
50%
Fuwa, H. ,
Kainuma, N. ,
Tachibana, K. ,
Tsukano, C. ,
Satake, M. &
Sasaki, M. ,
2004 10月 4 ,
In: Chemistry - A European Journal. 10 ,
19 ,
p. 4894-4909 16 p. 研究成果: Article › 査読
Double Bond
100%
Polycyclic Ether
100%
Structure-Activity Relationship
100%
Atom
100%
Total Synthesis
100%
Oikawa, M. ,
Tanaka, T. ,
Kusumoto, S. &
Sasaki, M. ,
2004 1月 19 ,
In: Tetrahedron Letters. 45 ,
4 ,
p. 787-790 4 p. 研究成果: Article › 査読
Hydroxyl Group
100%
Saccharide
100%
Immobilization
100%
Synthesis (Chemical)
100%
Polymer
100%
Sasaki, M. ,
Ebine, M. ,
Takagi, H. ,
Takakura, H. ,
Shida, T. ,
Satake, M. ,
Oshima, Y. ,
Igarashi, T. &
Yasumoto, T. ,
2004 4月 29 ,
In: Organic letters. 6 ,
9 ,
p. 1501-1504 4 p. 研究成果: Article › 査読
Synthesis (Chemical)
100%
Diastereomer
50%
Toxin
50%
Polycyclic Ether
50%
13C NMR Data
50%
2003
Ito, E. ,
Suzuki-Toyota, F. ,
Toshimori, K. ,
Fuwa, H. ,
Tachibana, K. ,
Satake, M. &
Sasaki, M. ,
2003 12月 ,
In: Toxicon. 42 ,
7 ,
p. 733-740 8 p. 研究成果: Article › 査読
Ciguatera
100%
Toxin
100%
Mouse
100%
Toxicity
50%
Toxic Injury
50%
Sasaki, M. ,
Iwamuro, Y. ,
Nemoto, J. &
Oikawa, M. ,
2003 8月 11 ,
In: Tetrahedron Letters. 44 ,
33 ,
p. 6199-6201 3 p. 研究成果: Article › 査読
Azaspiracid
100%
Anion
33%
Epoxide
33%
Toxic Injury
33%
Dithiane
33%
Fuwa, H. ,
Kainuma, N. ,
Satake, M. &
Sasaki, M. ,
2003 8月 4 ,
In: Bioorganic and Medicinal Chemistry Letters. 13 ,
15 ,
p. 2519-2522 4 p. 研究成果: Article › 査読
Biological Product
100%
Synthesis
100%
Toxicity
50%
Toxin
50%
Structure Activity Relationship
50%
Polyether
100%
Cytotoxic
100%
Radical Cyclization
50%
Tetrahydrofuran
50%
Total Synthesis
100%
Synthesis (Chemical)
75%
Polycyclic Ether
50%
Toxin
25%
Structure-Activity Relationship
25%
Total Synthesis
100%
Hydroxyl Group
50%
Polyether
50%
Marine Natural Products
50%
Synthesis (Chemical)
50%
2002
Sasaki, M. ,
Ishikawa, M. ,
Fuwa, H. &
Tachibana, K. ,
2002 3月 4 ,
In: Tetrahedron. 58 ,
10 ,
p. 1889-1911 23 p. 研究成果: Article › 査読
Synthesis (Chemical)
100%
Ciguatoxin
66%
Polycyclic Ether
66%
Suzuki Coupling
66%
Double Bond
33%
Ciguatoxin
100%
Conformational Isomer
100%
Radical Cyclization
66%
Ring Closing Metathesis
66%
Cyclic Structure
66%
Takakura, H. ,
Sasaki, M. ,
Honda, S. &
Tachibana, K. ,
2002 8月 8 ,
In: Organic letters. 4 ,
16 ,
p. 2771-2774 4 p. 研究成果: Article › 査読
Ciguatoxin
100%
Synthesis (Chemical)
50%
Coupling Reaction
50%
Total Synthesis
50%
Synthesis (Chemical)
100%
Polycyclic Ether
50%
Polyether
50%
Coupling Reaction
50%
Total Synthesis
50%
Fuwa, H. ,
Kainuma, N. ,
Tachibana, K. &
Sasaki, M. ,
2002 12月 18 ,
In: Journal of the American Chemical Society. 124 ,
50 ,
p. 14983-14992 10 p. 研究成果: Article › 査読