A large, square-shaped, DNA origami nanopore with sealing function on a giant vesicle membrane

Shoji Iwabuchi, Ibuki Kawamata, Satoshi Murata, Shin Ichiro M. Nomura

研究成果: ジャーナルへの寄稿学術論文査読

18 被引用数 (Scopus)

抄録

Intaking molecular information from the external environment is essential for the normal functioning of artificial cells/molecular robots. Herein, we report the design and function of a membrane nanopore using a DNA origami square tube with a cross-section of 100 nm2. When the nanopore is added to a giant vesicle that mimics a cell membrane, the permeation of large external hydrophilic fluorescent molecules is observed. Furthermore, the addition of up to four ssDNA strands enables size-based selective transport of molecules. A controllable artificial nanopore should facilitate the communication between the vesicle components and their environment.

本文言語英語
ページ(範囲)2990-2993
ページ数4
ジャーナルChemical Communications
57
24
DOI
出版ステータス出版済み - 2021 3月 25

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