TY - JOUR
T1 - A primary Barrett’s adenocarcinoma with a squamous cell carcinoma component
AU - Takeuchi, Akio
AU - Hatta, Waku
AU - Koike, Tomoyuki
AU - Saito, Masahiro
AU - Jin, Xiaoyi
AU - Asanuma, Kiyotaka
AU - Uno, Kaname
AU - Asano, Naoki
AU - Imatani, Akira
AU - Fujishima, Fumiyoshi
AU - Masamune, Atsushi
N1 - Publisher Copyright:
© 2019 Japanese Society of Internal Medicine. All rights reserved.
PY - 2019
Y1 - 2019
N2 - The present report describes an extremely rare case of Barrett’s adenocarcinoma (BAC) with a squamous cell carcinoma (SCC) component. A 55-year-old man was diagnosed with esophageal adenocarcinoma on Barrett’s esophagus. The patient underwent endoscopic submucosal dissection, but the pathology revealed deep submucosal invasive, moderately differentiated tubular adenocarcinoma and focal SCC with vascular invasion. In addition, morphological transition between adenocarcinoma and SCC components was confirmed. The patient underwent additional surgery, which revealed lymph node metastasis, and then received S-1 adjuvant chemotherapy. Based on the pathological findings, the transdifferentiation process may have a role in the histogenesis of this tumor.
AB - The present report describes an extremely rare case of Barrett’s adenocarcinoma (BAC) with a squamous cell carcinoma (SCC) component. A 55-year-old man was diagnosed with esophageal adenocarcinoma on Barrett’s esophagus. The patient underwent endoscopic submucosal dissection, but the pathology revealed deep submucosal invasive, moderately differentiated tubular adenocarcinoma and focal SCC with vascular invasion. In addition, morphological transition between adenocarcinoma and SCC components was confirmed. The patient underwent additional surgery, which revealed lymph node metastasis, and then received S-1 adjuvant chemotherapy. Based on the pathological findings, the transdifferentiation process may have a role in the histogenesis of this tumor.
KW - Barrett’s adenocarcinoma
KW - Morphological transition
KW - Squamous cell carcinoma component
UR - http://www.scopus.com/inward/record.url?scp=85071788012&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85071788012&partnerID=8YFLogxK
U2 - 10.2169/internalmedicine.2722-19
DO - 10.2169/internalmedicine.2722-19
M3 - Article
C2 - 31118396
AN - SCOPUS:85071788012
SN - 0918-2918
VL - 58
SP - 2467
EP - 2472
JO - Internal Medicine
JF - Internal Medicine
IS - 17
ER -