Here, we report a three-component coupling reaction approach between an aldehyde, an allyloxyamine, and a maleimide toward isoquinoline derivatives. At first, an oxime O-allylic ether, prepared by dehydrative condensation of the aldehyde and the allyloxyamine, was reacted with the maleimide in the presence of a Pd2+ species. The cycloadduct obtained was then subjected to the Heck cyclization employing a Pd0 species to give thermodynamically stable diastereomer of isoquinoline derivatives selectively in 25-78% yields.
|出版ステータス||Published - 2007 6月 11|
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