TY - JOUR
T1 - Actin-related proteins localized in the nucleus
T2 - From discovery to novel roles in nuclear organization
AU - Oma, Yukako
AU - Harata, Masahiko
PY - 2011
Y1 - 2011
N2 - The actin family consists of conventional actin and actin-related proteins (ARPs), and the members show moderate similarity and share the same basal structure. Following the finding of various ARPs in the cytoplasm in the 1990s, multiple subfamilies that are localized predominantly in the nucleus were identified. Consistent with these cytological observations, subsequent biochemical analyses revealed the involvement of the nuclear ARPs in ATP-dependent chromatin-remodeling and histone acetyltransferase complexes. In addition to their contribution to chromatin remodeling, recent studies have shown that nuclear ARPs have roles in the organization of the nucleus that are independent of the activity of the above-mentioned complexes. Therefore, nuclear ARPs are recognized as novel key regulators of genome function, and affect not only the remodeling of chromatin but also the spatial arrangement and dynamics of chromatin within the nucleus.
AB - The actin family consists of conventional actin and actin-related proteins (ARPs), and the members show moderate similarity and share the same basal structure. Following the finding of various ARPs in the cytoplasm in the 1990s, multiple subfamilies that are localized predominantly in the nucleus were identified. Consistent with these cytological observations, subsequent biochemical analyses revealed the involvement of the nuclear ARPs in ATP-dependent chromatin-remodeling and histone acetyltransferase complexes. In addition to their contribution to chromatin remodeling, recent studies have shown that nuclear ARPs have roles in the organization of the nucleus that are independent of the activity of the above-mentioned complexes. Therefore, nuclear ARPs are recognized as novel key regulators of genome function, and affect not only the remodeling of chromatin but also the spatial arrangement and dynamics of chromatin within the nucleus.
KW - Actin-related protein
KW - Arp
KW - Chromatin
KW - Chromatin remodeling
KW - Nuclear organization
KW - Nucleus
UR - http://www.scopus.com/inward/record.url?scp=79952650662&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=79952650662&partnerID=8YFLogxK
U2 - 10.4161/nucl.2.1.14510
DO - 10.4161/nucl.2.1.14510
M3 - Review article
C2 - 21647298
AN - SCOPUS:79952650662
SN - 0115-2300
VL - 2
SP - 38
EP - 46
JO - Nucleus
JF - Nucleus
IS - 1
ER -