Activation of adenosine A1-receptor pathway induces edema formation in the pancreas of rats

Akihiko Satoh, Tooru Shimosegawa, Kennichi Satoh, Harunobu Ito, Yutaka Kohno, Atsushi Masamune, Motokazu Fujita, Takayoshi Toyota

研究成果: ジャーナルへの寄稿学術論文査読

33 被引用数 (Scopus)


Background and Aims: Adenosine has been shown to modulate various pathophysiologic conditions through receptor-mediated mechanisms. However, the role of adenosine in the pathogenesis of acute pancreatitis has not been described. We examined the effect of adenosine-receptor stimulation or inhibition on the pathologic changes of the pancreas. Methods: Rats received intraperitoneal injections of selective agonists of A1, A2a, and A3 adenosine receptors: 2-chloro-N6-cyclopen-tyladenosine (CCPA), CGS-21680 (CGS), or 1-deoxy-1-[6-[[(3-iodophenyl)methyl]amino]-9H-purin-9-yl]-N-methy l-β-D-ribofuranuronamide (IB-MECA), respectively. Serum amylase activity and pathologic changes of the pancreas were evaluated. The effects of a specific A1-receptor antagonist (FK-838) on the pathologic findings of cerulein- and taurocholate-induced pancreatitis were also examined. Results: Administration of a selective A1 agonist induced hyperamylasemia and morphologic changes in the pancreas characterized by interstitial edema and leukocyte infiltration; neither A2a nor A3 agonist produced such changes. Treatment with an A1-receptor antagonist significantly attenuated the outcome induced by A1 agonist stimulation. In addition, the A1-receptor antagonist significantly ameliorated pancreatic edema in both pancreatitis models, although it did not improve the acinar cell damage of the pancreas or the increase of serum amylase. Conclusions: Activation of the adenosine A1-receptor pathway may have an important role in the pathogenesis of acute pancreatitis.

出版ステータス出版済み - 2000


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