Alkoxyacetyl (AAc) group as a useful linker for organic synthesis on poly(ethylene glycol) support

Masato Oikawa; Minoru Ikoma; Makoto Sasaki

doi:10.1016/j.tetlet.2004.01.103

Alkoxyacetyl (AAc) group as a useful linker for organic synthesis on poly(ethylene glycol) support

Masato Oikawa, Minoru Ikoma, Makoto Sasaki

生命科学研究科・分子化学生物学専攻

研究成果: Article › 査読

12 被引用数 (Scopus)

抄録

An alkoxyacetyl group (AAc) group was found to be an efficient linker for high-throughput synthesis of small molecules on a soluble polymer support. The linker allows high-yield loading of alcohols and phenols either by conventional carbodiimide-mediated esterification or transesterification using Yb(OTf) ₃. Chemoselective cleavage to release small molecules is attained also by Yb(OTf)₃ or TMSCHN₂. The preparation, protocols for loading and releasing of small molecules, and an application to the Ugi four-component coupling reaction are reported.

本文言語	English
ページ（範囲）	2371-2375
ページ数	5
ジャーナル	Tetrahedron Letters
巻	45
号	11
DOI	https://doi.org/10.1016/j.tetlet.2004.01.103
出版ステータス	Published - 2004 2月 8

ASJC Scopus subject areas

生化学
創薬
有機化学

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10.1016/j.tetlet.2004.01.103

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AU - Ikoma, Minoru

AU - Sasaki, Makoto

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AB - An alkoxyacetyl group (AAc) group was found to be an efficient linker for high-throughput synthesis of small molecules on a soluble polymer support. The linker allows high-yield loading of alcohols and phenols either by conventional carbodiimide-mediated esterification or transesterification using Yb(OTf) 3. Chemoselective cleavage to release small molecules is attained also by Yb(OTf)3 or TMSCHN2. The preparation, protocols for loading and releasing of small molecules, and an application to the Ugi four-component coupling reaction are reported.

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Alkoxyacetyl (AAc) group as a useful linker for organic synthesis on poly(ethylene glycol) support

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