TY - JOUR
T1 - An association study on polymorphisms in the PEA15, ENTPD4, and GAS2L1 genes and schizophrenia
AU - Saito, Atsushi
AU - Fujikura-Ouchi, Yuta
AU - Ito, Chihiro
AU - Matsuoka, Hiroo
AU - Shimoda, Kazutaka
AU - Akiyama, Kazufumi
N1 - Funding Information:
The present study was supported by Dokkyo Medical University, Young Investigator Award , and the Kobayashi Magobe Memorial Medical Foundation .
PY - 2011/1/30
Y1 - 2011/1/30
N2 - Our previous study examined a number of methamphetamine (METH)/phencyclidine (PCP)-reactive tags in rat brain, using a serial analysis of gene expression. Among human homologous genes, which matched METH/PCP-reactive tags, three human genes were identified: phosphoprotein enriched in astrocyte 15 (PEA15), ectonucleoside triphosphate diphosphohydrolase 4 (ENTPD4), and growth arrest-specific 2 like 1 (GAS2L1), which are localized in the chromosome 1q21.1, 8p21.3, and 22q12.2, respectively. We postulated that these genes are plausible candidate genes that play a role in pathogenesis for schizophrenia. Using tagging single-nucleotide polymorphisms (SNPs), we performed a case-control comparison for three SNPs in the PEA15 gene, and six SNPs in the GAS2L1 gene in a sample set of subjects (240 schizophrenia patients and 286 control subjects). Twelve SNPs in the ENTPD4 gene were analyzed in a subset of subjects (94 schizophrenia patients and 94 control subjects). No single SNP displayed a significant difference regarding the allelic frequency or genotypic distribution between the affected cases and controls for any of the genes examined. There was neither a significant difference in the frequency of three marker haplotype in the PEA15 gene or of six marker haplotype in the GAS2L1 gene between the cases and controls. The present study fails to provide evidence for the contribution of PEA15, ENTPD4, and GAS2L1 genes to the etiology of schizophrenia in the Japanese population.
AB - Our previous study examined a number of methamphetamine (METH)/phencyclidine (PCP)-reactive tags in rat brain, using a serial analysis of gene expression. Among human homologous genes, which matched METH/PCP-reactive tags, three human genes were identified: phosphoprotein enriched in astrocyte 15 (PEA15), ectonucleoside triphosphate diphosphohydrolase 4 (ENTPD4), and growth arrest-specific 2 like 1 (GAS2L1), which are localized in the chromosome 1q21.1, 8p21.3, and 22q12.2, respectively. We postulated that these genes are plausible candidate genes that play a role in pathogenesis for schizophrenia. Using tagging single-nucleotide polymorphisms (SNPs), we performed a case-control comparison for three SNPs in the PEA15 gene, and six SNPs in the GAS2L1 gene in a sample set of subjects (240 schizophrenia patients and 286 control subjects). Twelve SNPs in the ENTPD4 gene were analyzed in a subset of subjects (94 schizophrenia patients and 94 control subjects). No single SNP displayed a significant difference regarding the allelic frequency or genotypic distribution between the affected cases and controls for any of the genes examined. There was neither a significant difference in the frequency of three marker haplotype in the PEA15 gene or of six marker haplotype in the GAS2L1 gene between the cases and controls. The present study fails to provide evidence for the contribution of PEA15, ENTPD4, and GAS2L1 genes to the etiology of schizophrenia in the Japanese population.
KW - Ectonucleoside triphosphate diphosphohydrolase 4 (ENTPD4)
KW - Growth arrest-specific 2 like 1 (GAS2L1)
KW - Phosphoprotein enriched in astrocyte 15 (PEA15)
KW - Schizophrenia
KW - Serial analysis of gene expression (SAGE)
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U2 - 10.1016/j.psychres.2009.09.018
DO - 10.1016/j.psychres.2009.09.018
M3 - Article
C2 - 20537721
AN - SCOPUS:78650211601
SN - 0165-1781
VL - 185
SP - 9
EP - 15
JO - Psychiatry Research
JF - Psychiatry Research
IS - 1-2
ER -
