Antitumor effect of a novel fullerene-based photosensitizer with magnetic resonance imaging ability

Jian Liu; Masaya Yamamoto; Masatoshi Yamada; Shin Ichi Ohta; Akinaga Sonoda; Norihisa Nitta; Kiyoshi Murata; Yasuhiko Tabata

Antitumor effect of a novel fullerene-based photosensitizer with magnetic resonance imaging ability

Jian Liu, Masaya Yamamoto, Masatoshi Yamada, Shin Ichi Ohta, Akinaga Sonoda, Norihisa Nitta, Kiyoshi Murata, Yasuhiko Tabata

研究成果: Paper › 査読

抄録

A novel photosensitizer with both the tumor targetability and magnetic resonance imaging (MRI) activity was designed for efficient photodynamic therapy of tumor. Polyethylene glycol (PEG) was chemically coupled to C₆₀, while a diethylenetriaminepentaacetic acid (DTPA) residue was introduced to the PEG terminal of PEG-C₆₀ prepared. After the DTPA-introduced C ₆₀-PEG was mixed with gadolinium ions (Gd³⁺) in aqueous solution and injected intravenously into tumor-bearing mice, the MRI and photodynamic activities were investigated. Chelating incorporation of Gd ³⁺ ions enabled the C₆₀-PEG with tumor targetability to perform the tumor diagnosis and photodynamic therapy simultaneously. This diagnostic and therapeutic hybrid system is a promising tool to enhance the efficacy in photodynamic tumor therapy.

本文言語	English
ページ	1987
ページ数	1
出版ステータス	Published - 2006
外部発表	はい
イベント	55th SPSJ Annual Meeting - Nagoya, Japan 継続期間: 2006 5月 24 → 2006 5月 26

Other

Other	55th SPSJ Annual Meeting
国/地域	Japan
City	Nagoya
Period	06/5/24 → 06/5/26

ASJC Scopus subject areas

工学（全般）

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引用スタイル

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title = "Antitumor effect of a novel fullerene-based photosensitizer with magnetic resonance imaging ability",

abstract = "A novel photosensitizer with both the tumor targetability and magnetic resonance imaging (MRI) activity was designed for efficient photodynamic therapy of tumor. Polyethylene glycol (PEG) was chemically coupled to C60, while a diethylenetriaminepentaacetic acid (DTPA) residue was introduced to the PEG terminal of PEG-C60 prepared. After the DTPA-introduced C 60-PEG was mixed with gadolinium ions (Gd3+) in aqueous solution and injected intravenously into tumor-bearing mice, the MRI and photodynamic activities were investigated. Chelating incorporation of Gd 3+ ions enabled the C60-PEG with tumor targetability to perform the tumor diagnosis and photodynamic therapy simultaneously. This diagnostic and therapeutic hybrid system is a promising tool to enhance the efficacy in photodynamic tumor therapy.",

keywords = "Antitumor activity, Fullerene, Magnetic resonance imaging, Photodynamic therapy, Tumor targeting",

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AU - Liu, Jian

AU - Yamamoto, Masaya

AU - Yamada, Masatoshi

AU - Ohta, Shin Ichi

AU - Sonoda, Akinaga

AU - Nitta, Norihisa

AU - Murata, Kiyoshi

AU - Tabata, Yasuhiko

PY - 2006

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N2 - A novel photosensitizer with both the tumor targetability and magnetic resonance imaging (MRI) activity was designed for efficient photodynamic therapy of tumor. Polyethylene glycol (PEG) was chemically coupled to C60, while a diethylenetriaminepentaacetic acid (DTPA) residue was introduced to the PEG terminal of PEG-C60 prepared. After the DTPA-introduced C 60-PEG was mixed with gadolinium ions (Gd3+) in aqueous solution and injected intravenously into tumor-bearing mice, the MRI and photodynamic activities were investigated. Chelating incorporation of Gd 3+ ions enabled the C60-PEG with tumor targetability to perform the tumor diagnosis and photodynamic therapy simultaneously. This diagnostic and therapeutic hybrid system is a promising tool to enhance the efficacy in photodynamic tumor therapy.

AB - A novel photosensitizer with both the tumor targetability and magnetic resonance imaging (MRI) activity was designed for efficient photodynamic therapy of tumor. Polyethylene glycol (PEG) was chemically coupled to C60, while a diethylenetriaminepentaacetic acid (DTPA) residue was introduced to the PEG terminal of PEG-C60 prepared. After the DTPA-introduced C 60-PEG was mixed with gadolinium ions (Gd3+) in aqueous solution and injected intravenously into tumor-bearing mice, the MRI and photodynamic activities were investigated. Chelating incorporation of Gd 3+ ions enabled the C60-PEG with tumor targetability to perform the tumor diagnosis and photodynamic therapy simultaneously. This diagnostic and therapeutic hybrid system is a promising tool to enhance the efficacy in photodynamic tumor therapy.

KW - Antitumor activity

KW - Fullerene

KW - Magnetic resonance imaging

KW - Photodynamic therapy

KW - Tumor targeting

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T2 - 55th SPSJ Annual Meeting

Y2 - 24 May 2006 through 26 May 2006

ER -

Antitumor effect of a novel fullerene-based photosensitizer with magnetic resonance imaging ability

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