Asymmetric total synthesis of (–)-rossinone A

Katsuya Saito, Kazuki Kurasawa, Chiaki Takino, Shigefumi Kuwahara, Masaru Enomoto

    研究成果: Article査読

    1 被引用数 (Scopus)

    抄録

    The asymmetric total synthesis of (–)-rossinone A, a meroterpene exhibiting a range of pharmacologically important biological activities, has been accomplished for the first time from geraniol by a concise eight-step sequence that involves the Horner–Wadsworth–Emmons reaction of an aldehyde derived from a geranylated hydroquinone intermediate with a chiral phosphonate prepared via the highly diastereoselective Davis oxidation of a known oxazolidinone derivative.

    本文言語English
    論文番号153456
    ジャーナルTetrahedron Letters
    84
    DOI
    出版ステータスPublished - 2021 11月 9

    ASJC Scopus subject areas

    • 生化学
    • 創薬
    • 有機化学

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