TY - JOUR
T1 - Biosynthesis of indole diterpenes
T2 - a reconstitution approach in a heterologous host
AU - Ozaki, Taro
AU - Minami, Atsushi
AU - Oikawa, Hideaki
N1 - Funding Information:
This work was financially supported by Grants-in-Aid for Scientific Research from the Ministry of Education, Culture, Sports, Science and Technology, Japan (JSPS KAKENHI Grant Number JP19H02891 (H. O.), JP22H02204 (A. M.), JP16H06446 (A. M.) and JP19H04635 (T. O.)) and Institute for Fermentation, Osaka (IFO), Grant Number G-2022-3-011 (A. M.).
Publisher Copyright:
© 2023 The Royal Society of Chemistry.
PY - 2022/11/2
Y1 - 2022/11/2
N2 - Covering: 2013 to 2022 In this review, we provide an overview elucidating the biosynthetic pathway and heterologous production of fungal indole diterpenes (IDTs). Based on the studies of six IDT biosynthesis, we extracted nature's strategy: (1) two-stage synthesis for the core scaffold and platform intermediates, and (2) late-stage modifications for installing an additional cyclic system on the indole ring. Herein, we describe reconstitution studies applying this strategy to the synthesis of highly elaborated IDTs. We also discuss its potential for future biosynthetic engineering.
AB - Covering: 2013 to 2022 In this review, we provide an overview elucidating the biosynthetic pathway and heterologous production of fungal indole diterpenes (IDTs). Based on the studies of six IDT biosynthesis, we extracted nature's strategy: (1) two-stage synthesis for the core scaffold and platform intermediates, and (2) late-stage modifications for installing an additional cyclic system on the indole ring. Herein, we describe reconstitution studies applying this strategy to the synthesis of highly elaborated IDTs. We also discuss its potential for future biosynthetic engineering.
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U2 - 10.1039/d2np00031h
DO - 10.1039/d2np00031h
M3 - Review article
C2 - 36321441
AN - SCOPUS:85141757592
SN - 0265-0568
VL - 40
SP - 202
EP - 213
JO - Natural Product Reports
JF - Natural Product Reports
IS - 1
ER -