@article{7c953853e6cd434391499dd6a6b05c7f,
title = "Cell Inertia: Predicting Cell Distributions in Lung Vasculature to Optimize Re-endothelialization",
abstract = "We created a transient computational fluid dynamics model featuring a particle deposition probability function that incorporates inertia to quantify the transport and deposition of cells in mouse lung vasculature for the re-endothelialization of the acellular organ. Our novel inertial algorithm demonstrated a 73% reduction in cell seeding efficiency error compared to two established particle deposition algorithms when validated with experiments based on common clinical practices. We enhanced the uniformity of cell distributions in the lung vasculature by increasing the injection flow rate from 3.81 ml/min to 9.40 ml/min. As a result, the cell seeding efficiency increased in both the numerical and experimental results by 42 and 66%, respectively.",
keywords = "cell seeding, computational fluid dynamics, inertia, lung regeneration, lung tissue engineering, re-endothelialization",
author = "Chan, {Jason K.D.} and Chadwick, {Eric A.} and Daisuke Taniguchi and Mohammadali Ahmadipour and Takaya Suzuki and David Romero and Cristina Amon and Waddell, {Thomas K.} and Golnaz Karoubi and Aimy Bazylak",
note = "Funding Information: This work was supported by the Natural Sciences and Engineering Research Council of Canada (NSERC) Discovery Grants Program, the Canada Research Chairs Program, the Canada First Research Excellence Fund: Medicine by Design Program, the Canadian Institutes of Health Research, the NSERC Collaborative Health Research Projects, and the University Hospital Network at the University of Toronto. Graduate scholarships awarded to JC from NSERC Alexander Graham Bell Canada Scholarships Masters Award, Barbara and Frank Milligan Fellowship for Biomedical Engineering, Sir James Lougheed Award of Distinction and Ontario Graduate Scholarship are gratefully acknowledged. Publisher Copyright: Copyright {\textcopyright} 2022 Chan, Chadwick, Taniguchi, Ahmadipour, Suzuki, Romero, Amon, Waddell, Karoubi and Bazylak.",
year = "2022",
month = apr,
day = "27",
doi = "10.3389/fbioe.2022.891407",
language = "English",
volume = "10",
journal = "Frontiers in Bioengineering and Biotechnology",
issn = "2296-4185",
publisher = "Frontiers Media S. A.",
}