TY - GEN
T1 - Change in material and structural parameters of bone mechanical function during long-bone regeneration
AU - Ishimoto, Takuya
AU - Nakano, Takayoshi
AU - Umakoshi, Yukichi
AU - Yamamoto, Masaya
AU - Tabata, Yasuhiko
PY - 2007
Y1 - 2007
N2 - Bone mechanical function is given as a result of the material and structural parameters of bone tissue. We previously reported that the material parameter of regenerated bone can be evaluated dominantly using two indices of the density and the preferred orientation degree of biological apatite (BAp). In addition, bone morphology remarkably changes during bone regeneration, which may lead to a dynamic change in the mechanical function of whole bone. In this study, therefore, material and structural parameters of regenerated bone are analyzed separately. A 5-mm-long defect was introduced in rabbit ulna and spontaneously regenerated, and then a three-point bending test was conducted at the regenerated portion. The important parameter which dominantly controls the whole bone mechanical function shifts from a structural to material parameter during bone regeneration. Moreover, it was statistically demonstrated that the increase in the material parameter is strongly determined by recovery of the orientation degree of the BAp c-axis.
AB - Bone mechanical function is given as a result of the material and structural parameters of bone tissue. We previously reported that the material parameter of regenerated bone can be evaluated dominantly using two indices of the density and the preferred orientation degree of biological apatite (BAp). In addition, bone morphology remarkably changes during bone regeneration, which may lead to a dynamic change in the mechanical function of whole bone. In this study, therefore, material and structural parameters of regenerated bone are analyzed separately. A 5-mm-long defect was introduced in rabbit ulna and spontaneously regenerated, and then a three-point bending test was conducted at the regenerated portion. The important parameter which dominantly controls the whole bone mechanical function shifts from a structural to material parameter during bone regeneration. Moreover, it was statistically demonstrated that the increase in the material parameter is strongly determined by recovery of the orientation degree of the BAp c-axis.
KW - Biological apatite (BAp)
KW - Bone regeneration
KW - Microbeam X-ray diffraction (μXRD)
KW - Section modulus
KW - Three-point bending test
KW - Ultimate load
KW - Ultimate stress
UR - http://www.scopus.com/inward/record.url?scp=38349143709&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=38349143709&partnerID=8YFLogxK
U2 - 10.4028/0-87849-462-6.1451
DO - 10.4028/0-87849-462-6.1451
M3 - Conference contribution
AN - SCOPUS:38349143709
SN - 0878494626
SN - 9780878494620
T3 - Materials Science Forum
SP - 1451
EP - 1454
BT - Selected, peer reviewed papers from The Sixth Pacific Rim International Conference on Advanced Materials and Processing, PRICM 6
PB - Trans Tech Publications Ltd
T2 - 6th Pacific Rim International Conference on Advanced Materials and Processing, PRICM 6
Y2 - 5 November 2007 through 9 November 2007
ER -