@inproceedings{eab2125ea16349658748071501a1e4db,
title = "Characteristics of surface behavior and osteoinductivity of biomimetic ceramic scaffold",
abstract = "We previously reported functionally graded hydroxyapatite (fg-HAp) with the characteristics of blood permeability into the bulk and osteoinduction by adding low dose of bone morphogenetic protein-2 (BMP-2). In this study, we evaluated the bioactivity of the obtained dense HAp bodies in a simulated body fluid (SBF) and the osteoinductive activity with or without SBF treatment in vivo. The fg-HAp·SBF was prepared by immersing the fg-HAp in the SBF solution at 14 days and the surface structure was observed by SEM. The fg-HAp·SBF showed fine bone-like crystal on the surface of the HAp. Ectopic bone formation occurred in the fg-HAp/BMP-2 (1.0, 0.5μg) system at 3 weeks, while only in the fg-HAp·SBF/BMP-2 (1.0μg), bone induction was found. The histological finding showed body fluid permeation into the fg-HAp·SBF bulk and bone formation were obserbed.",
keywords = "Biomimetic, Ceramic scaffold, Osteoinductivity, Surface behavior",
author = "J. Tazaki and M. Murata and T. Akazawa and M. Yamamoto and K. Ito and J. Hino and Y. Minamida and H. Nagayasu and M. Arisue and T. Shibata and Y. Tabata",
year = "2013",
doi = "10.4028/www.scientific.net/KEM.529-530.50",
language = "English",
isbn = "9783037855171",
series = "Key Engineering Materials",
publisher = "Trans Tech Publications Ltd",
number = "1",
pages = "50--54",
booktitle = "Bioceramics 24",
edition = "1",
note = "24th Symposium and Annual Meeting of International Society for Ceramics in Medicine, ISCM 2012 ; Conference date: 21-10-2012 Through 24-10-2012",
}