抄録
An enantioselective Mannich-type reaction between enamides, serving as aliphatic imine equivalents, and thiazolones or an azlactone, serving as α-amino acid derived pronucleophiles, was investigated using a chiral phosphoric acid catalyst. By using thiazolones, Mannich adducts with a tetrasubstituted chiral carbon center at the α-position and an aliphatic substituent at the β-position were efficiently obtained with high diastereo- and enantioselectivities.
| 本文言語 | English |
|---|---|
| ページ（範囲） | 2521-2523 |
| ページ数 | 3 |
| ジャーナル | Organic letters |
| 巻 | 18 |
| 号 | 11 |
| DOI | |
| 出版ステータス | Published - 2016 6月 3 |
ASJC Scopus subject areas
- 生化学
- 物理化学および理論化学
- 有機化学