Chronic cadmium exposure-induced renal anemia in ovariectomized rats

Hideaki Hiratsuka, Osamu Katsuta, Naoto Toyota, Minoru Tsuchitani, Takashi Umemura, Fumiaki Marumo

研究成果: Article査読

29 被引用数 (Scopus)


Cadmium (Cd) chloride was intravenously injected at doses of 0.05 and 0.5 mg/kg/day in ovariectomized rats for 50 weeks, and the chronic Cd exposure-induced nephrotoxicity and anemia were investigated. The rats treated with 0.05 mg/kg Cd showed no apparent hematological, urinary, and histopathological abnormalities. In the 0.5-mg/kg group, renal tubular disorders became marked at 16 weeks, and cortical fibrosis with glomerular dysfunction appeared at 50 weeks. Anemia occurred at 12 weeks in the 0.5-mg/kg group and became increasingly marked with time. The mean corpuscular volume (MCV) and mean corpuscular hemoglobin (MCH) were decreased at 12 and 25 weeks; however, the decreases of MCV and MCH disappeared at 50 weeks. A slight decrease in mean corpuscular hemoglobin concentration was noted at 50 weeks. The blood chemistry data from the same group revealed a decrease in plasma iron levels and an increase in total iron binding capacity throughout the administration period. The erythropoietin (EPO) level was increased as the hemoglobin level decreased at 12 weeks, whereas the EPO level was not elevated even when the hemoglobin level was decreased at 50 weeks. These findings showed that renal anemia also occurred in addition to the iron deficiency anemia at 50 weeks.

ジャーナルToxicology and Applied Pharmacology
出版ステータスPublished - 1996 4月

ASJC Scopus subject areas

  • 毒物学
  • 薬理学


「Chronic cadmium exposure-induced renal anemia in ovariectomized rats」の研究トピックを掘り下げます。これらがまとまってユニークなフィンガープリントを構成します。