Comparison of hepatitis B virus genotype B and C patients in Japan in terms of family history and maternal age at birth

Kosuke Sato, Jun Inoue, Takehiro Akahane, Tomoo Kobayashi, Masashi Ninomiya, Akitoshi Sano, Mio Tsuruoka, Masazumi Onuki, Satoko Sawahashi, Keishi Ouchi, Kotaro Doi, Kengo Watanabe, Hirofumi Niitsuma, Atsushi Masamune

研究成果: ジャーナルへの寄稿学術論文査読

1 被引用数 (Scopus)

抄録

Aim: Hepatitis B virus of genotypes B (HBV/B) and C (HBV/C) prevails in Japan and patients with HBV/B have been known to be older than those with HBV/C, but the reason has remained unknown. We aimed to clarify the reason by focusing on the family history of HBV infection. Methods: In a total of 508 patients with chronic HBV infection, HBV genotype, patient age, and age of the mother at birth were compared. Results: Patient age was significantly older in HBV/B than in HBV/C, and the patient percentage with a family history of HBV infection was lower in HBV/B. When comparing maternal age at birth between the two genotypes, there was no significant difference in the overall patient population, but the proportion of older birth group (≥26 years old) was significantly lower in HBV/B (38.7% vs. 59.3%, p = 0.048) in patients with a family history of HBV infection in both mothers and siblings whose HBV were considered to be transmitted vertically. There was a negative correlation between maternal age at birth and patient age in this group, reflecting the fact that the age of childbearing is increasing recently in Japan. Because patients with HBV/B experience hepatitis B e antigen seroconversion at an earlier age, it was considered that HBV/B has become harder to transmit vertically in recent decades. Conclusion: The recent decrease in vertical transmission of HBV/B associated with an older childbearing age in Japan might be one of the reasons for the finding that HBV/B patients were older than HBV/C patients.

本文言語英語
ページ(範囲)773-779
ページ数7
ジャーナルHepatology Research
55
5
DOI
出版ステータス出版済み - 2025 5月

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