TY - JOUR
T1 - Complete Remission in Systemic Skin Interdigitating Dendritic Cell Sarcoma after ABVD Chemotherapy
AU - Kyogoku, Chieko
AU - Seki, Masanori
AU - Ogawa, Shinichi
AU - Miyamoto, Kana
AU - Ito, Yufu
AU - Kurita, Naoki
AU - Yokoyama, Yasuhisa
AU - Sakata-Yanagimoto, Mamiko
AU - Obara, Naoshi
AU - Hasegawa, Yuichi
AU - Fujishima, Fumiyoshi
AU - Ichinohasama, Ryo
AU - Nakamura, Shigeo
AU - Chiba, Shigeru
PY - 2015
Y1 - 2015
N2 - Interdigitating dendritic cell sarcoma (IDCS) is a rare and aggressive neoplasm that is thought to arise from dendritic cells. This disease usually involves the lymph nodes and, rarely, extra-nodal sites. We report a 62-year-old man presenting skin nodules in the head, body, and extremities, as well as bone marrow involvement. Morphologic analysis of a biopsied specimen from the skin lesion was consistent with IDCS. Immunohistochemical staining demonstrated that the tumor cells were positive for IDCS-associated antigens such as CD4, CD45, CD68 (KP-1), and S-100 protein. Complete remission was achieved by treatment with 6 cycles of ABVD (adriamycin, bleomycin, vinblastine, and dacarbazine) chemotherapy. Although the optimal treatment of IDSC remains unknown, the experience in the current case supports the notion that ABVD chemotherapy may be effective for IDCS, and further extends this idea to rare patients presenting multiple skin lesions.
AB - Interdigitating dendritic cell sarcoma (IDCS) is a rare and aggressive neoplasm that is thought to arise from dendritic cells. This disease usually involves the lymph nodes and, rarely, extra-nodal sites. We report a 62-year-old man presenting skin nodules in the head, body, and extremities, as well as bone marrow involvement. Morphologic analysis of a biopsied specimen from the skin lesion was consistent with IDCS. Immunohistochemical staining demonstrated that the tumor cells were positive for IDCS-associated antigens such as CD4, CD45, CD68 (KP-1), and S-100 protein. Complete remission was achieved by treatment with 6 cycles of ABVD (adriamycin, bleomycin, vinblastine, and dacarbazine) chemotherapy. Although the optimal treatment of IDSC remains unknown, the experience in the current case supports the notion that ABVD chemotherapy may be effective for IDCS, and further extends this idea to rare patients presenting multiple skin lesions.
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U2 - 10.3960/jslrt.55.33
DO - 10.3960/jslrt.55.33
M3 - Article
C2 - 26106005
AN - SCOPUS:84991993346
SN - 1346-4280
VL - 55
SP - 33
EP - 37
JO - Journal of clinical and experimental hematopathology : JCEH
JF - Journal of clinical and experimental hematopathology : JCEH
IS - 1
ER -