TY - JOUR
T1 - Concatenated mitochondrial DNA of the coccidian parasite Eimeria tenella
AU - Hikosaka, Kenji
AU - Nakai, Yutaka
AU - Watanabe, Yoh ichi
AU - Tachibana, Shin Ichiro
AU - Arisue, Nobuko
AU - Palacpac, Nirianne Marie Q.
AU - Toyama, Tomoko
AU - Honma, Hajime
AU - Horii, Toshihiro
AU - Kita, Kiyoshi
AU - Tanabe, Kazuyuki
N1 - Funding Information:
This work was supported by Grant-in-Aids for Scientific Research from the Ministry of Education, Culture, Sports, Science and Technology of Japan ( 18073013 ) and from Japan Society for Promotion of Sciences ( 18GS03140013 and 20390120 ). We would like to thank the Eimeria tenella genome project at the Sanger Institute, UK ( http://www.sanger.ac.uk/Projects/E_tenella ) for partial sequences in the design of some PCR primers.
PY - 2011/3
Y1 - 2011/3
N2 - Apicomplexan parasites of the genus Plasmodium, pathogens causing malaria, and the genera Babesia and Theileria, aetiological agents of piroplasmosis, are closely related. However, their mitochondrial (mt) genome structures are highly divergent: Plasmodium has a concatemer of 6-kb unit and Babesia/. Theileria a monomer of 6.6- to 8.2-kb with terminal inverted repeats. Fragmentation of ribosomal RNA (rRNA) genes and gene arrangements are remarkably distinctive. To elucidate the evolutionary origin of this structural divergence, we determined the mt genome of Eimeria tenella, pathogens of coccidiosis in domestic fowls. Analysis revealed that E. tenella mt genome was concatemeric with similar protein-coding genes and rRNA gene fragments to Plasmodium. Copy number was 50-fold of the nuclear genome. Evolution of structural divergence in the apicomplexan mt genomes is discussed.
AB - Apicomplexan parasites of the genus Plasmodium, pathogens causing malaria, and the genera Babesia and Theileria, aetiological agents of piroplasmosis, are closely related. However, their mitochondrial (mt) genome structures are highly divergent: Plasmodium has a concatemer of 6-kb unit and Babesia/. Theileria a monomer of 6.6- to 8.2-kb with terminal inverted repeats. Fragmentation of ribosomal RNA (rRNA) genes and gene arrangements are remarkably distinctive. To elucidate the evolutionary origin of this structural divergence, we determined the mt genome of Eimeria tenella, pathogens of coccidiosis in domestic fowls. Analysis revealed that E. tenella mt genome was concatemeric with similar protein-coding genes and rRNA gene fragments to Plasmodium. Copy number was 50-fold of the nuclear genome. Evolution of structural divergence in the apicomplexan mt genomes is discussed.
KW - Apicomplexa
KW - Eimeria
KW - Mitochondrial genome
KW - Mitochondrion
KW - Nuclear mitochondrial DNA
KW - Plasmodium
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U2 - 10.1016/j.mito.2010.10.003
DO - 10.1016/j.mito.2010.10.003
M3 - Article
C2 - 21047565
AN - SCOPUS:79251600171
SN - 1567-7249
VL - 11
SP - 273
EP - 278
JO - Mitochondrion
JF - Mitochondrion
IS - 2
ER -
