Concise synthesis of PM-94128 and Y-05460M-A

Masaru Enomoto; Shigefumi Kuwahara

doi:10.1021/jo9014968

Concise synthesis of PM-94128 and Y-05460M-A

Masaru Enomoto, Shigefumi Kuwahara

農学研究科・農芸化学専攻

研究成果: Article › 査読

17 被引用数 (Scopus)

抄録

(Chemical Equation Presented) The enantioselective total synthesis of PM-94128, a potent cytotoxin of microbial origin, was accomplished by a concise nine-step sequence of reactions in 14% overall yield from N-Boc-L-leucine. The synthesis of Y-05460M-A, a one-carbon lower homologue of PM-94128, was also achieved from N-Boc-L-valine by the same approach, which enabled its stereochemical determination.

本文言語	English
ページ（範囲）	7566-7569
ページ数	4
ジャーナル	Journal of Organic Chemistry
巻	74
号	19
DOI	https://doi.org/10.1021/jo9014968
出版ステータス	Published - 2009 10月 2

ASJC Scopus subject areas

有機化学

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10.1021/jo9014968

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Concise synthesis of PM-94128 and Y-05460M-A

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