Control-released hepatocyte growth factor enhances the efficacy of cardiomyocyte transplantation by increasing the survival rate of the donor cells

K. Tambara, G. U. Premaratne, Y. Sakakibara, H. Nakajima, N. Kanemitsu, M. Yamamoto, M. Ozeki, Y. Tabata, M. Komeda

研究成果: Conference contribution

抄録

The effect of simultaneous administration of control-released HGF on the efficacy of CM Tx in a rat myocardial infarction (MI) model was investigated. HGF-impregnated gelatin hydrogel sheets, which enable HGF to be released in situ over 2 weeks was developed. MI was created by ligating the left coronary artery in Lewis rats. The rats that developed moderate-sized MI were divided into GroupI, II and III. Transplanted CMs were found over the whole MI area in Group I, while few donor CMs were detected in the center of the scar in Group II. The result shows that simultaneous application of HGF-impregnated gelatin hydrogel sheets may enhance the efficacy of CM Tx by improving the survival rate of donor CMs in chronic MI.

本文言語English
ホスト出版物のタイトルTransactions - 7th World Biomaterials Congress
ページ724
ページ数1
出版ステータスPublished - 2004
外部発表はい
イベントTransactions - 7th World Biomaterials Congress - Sydney, Australia
継続期間: 2004 5月 17 → 2004 5月 21

出版物シリーズ

名前Transactions - 7th World Biomaterials Congress

Other

OtherTransactions - 7th World Biomaterials Congress
国/地域Australia
CitySydney
Period04/5/17 → 04/5/21

ASJC Scopus subject areas

  • 工学（全般）

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