TY - JOUR
T1 - COVID-19 infection and nanomedicine applications for development of vaccines and therapeutics
T2 - An overview and future perspectives based on polymersomes
AU - Al-Hatamleh, Mohammad A.I.
AU - Hatmal, Ma'mon M.
AU - Alshaer, Walhan
AU - Rahman, Engku Nur Syafirah E.A.
AU - Mohd-Zahid, Manali Haniti
AU - Alhaj-Qasem, Dina M.
AU - Yean, Chan Yean
AU - Alias, Iskandar Z.
AU - Jaafar, Juhana
AU - Ferji, Khalid
AU - Six, Jean Luc
AU - Uskoković, Vuk
AU - Yabu, Hiroshi
AU - Mohamud, Rohimah
N1 - Funding Information:
Both M.A.I. Al-Hatamleh and E.N.S.E.A. Rahman would like to acknowledge the Universiti Sains Malaysia (USM) Fellowship Scheme for providing financial support.
Funding Information:
This work was supported by Japan International Cooperation Agency ( JICA) Project for AUN/SEED-Net Special Program for Research against COVID-19 (SPRAC) [grant number 304/PPSP/6150186/A119 ].
Publisher Copyright:
© 2021 Elsevier B.V.
PY - 2021/4/5
Y1 - 2021/4/5
N2 - The severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2), which emerged in December 2019 and caused the coronavirus disease 2019 (COVID-19) pandemic, took the world by surprise with an unprecedented public health emergency. Since this pandemic began, extraordinary efforts have been made by scientists to understand the pathogenesis of COVID-19, and to fight the infection by providing various preventive, diagnostic and treatment opportunities based on either novel hypotheses or past experiences. Despite all the achievements, COVID-19 continues to be an accelerating health threat with no specifically approved vaccine or therapy. This review highlights the recent advances in COVID-19 infection, with a particular emphasis on nanomedicine applications that can help in the development of effective vaccines or therapeutics against COVID-19. A novel future perspective has been proposed in this review based on utilizing polymersome nano-objects for effectively suppressing the cytokine storm, which may reduce the severity of COVID-19 infection.
AB - The severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2), which emerged in December 2019 and caused the coronavirus disease 2019 (COVID-19) pandemic, took the world by surprise with an unprecedented public health emergency. Since this pandemic began, extraordinary efforts have been made by scientists to understand the pathogenesis of COVID-19, and to fight the infection by providing various preventive, diagnostic and treatment opportunities based on either novel hypotheses or past experiences. Despite all the achievements, COVID-19 continues to be an accelerating health threat with no specifically approved vaccine or therapy. This review highlights the recent advances in COVID-19 infection, with a particular emphasis on nanomedicine applications that can help in the development of effective vaccines or therapeutics against COVID-19. A novel future perspective has been proposed in this review based on utilizing polymersome nano-objects for effectively suppressing the cytokine storm, which may reduce the severity of COVID-19 infection.
KW - 2019-nCoV
KW - Coronavirus
KW - Cytokine storm
KW - Nanomedicine
KW - SARS-CoV-2
UR - http://www.scopus.com/inward/record.url?scp=85100447715&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85100447715&partnerID=8YFLogxK
U2 - 10.1016/j.ejphar.2021.173930
DO - 10.1016/j.ejphar.2021.173930
M3 - Article
C2 - 33545157
AN - SCOPUS:85100447715
SN - 0014-2999
VL - 896
JO - European Journal of Pharmacology
JF - European Journal of Pharmacology
M1 - 173930
ER -
