Design of an LCST-UCST-Like Thermoresponsive Zwitterionic Copolymer

Nobuyuki Morimoto, Masaya Yamamoto

研究成果: ジャーナルへの寄稿学術論文査読

11 被引用数 (Scopus)

抄録

Thermoresponsive polymers that possess both UCST- and LCST-like behaviors have generally been designed using diblock copolymers that are mostly composed of an LCST-like polymer and a UCST polymer. Herein, we prepared an LCST-UCST-type polymer composed of UCST-like thermoresponsive zwitterionic sulfabetaine methacrylate and nonthermoresponsive PEG methacrylate, ZB-PEG, by reversible addition-fragmentation chain transfer (RAFT) copolymerization. By adjusting the PEG composition, ZB-PEG formed a mesoglobule, a microglobule, and the dissociated states in phosphate-buffered saline (PBS). These states were found to be reversible via temperature control. Moreover, this behavior showed high reversibility and succeeded in stabilizing horseradish peroxidase (HRP) in the dilute condition. Such thermoresponsive ZB-PEG can be applied over a wide range of applications in biotechnology and other fields.

本文言語英語
ページ(範囲)3261-3269
ページ数9
ジャーナルLangmuir
37
11
DOI
出版ステータス出版済み - 2021 3月 23

フィンガープリント

「Design of an LCST-UCST-Like Thermoresponsive Zwitterionic Copolymer」の研究トピックを掘り下げます。これらがまとまってユニークなフィンガープリントを構成します。

引用スタイル