Design of guaiazulene derivatives-conjugated podophyllotoxin nano-prodrug toward anticancer drug delivery

Kiyotaka Maruoka, Yoshitaka Koseki, Anh Thi Ngoc Dao, Ryuju Suzuki, Anudari Batbayar, Nagaki Sugeno, Hirohito Umezawa, Hitoshi Kasai

研究成果: ジャーナルへの寄稿学術論文査読

抄録

In nanoparticle-based drug delivery systems, dispersion stability is one of the most significant factors controlling drug efficacy and side effects. Herein, we synthesized guaiazulene derivatives-conjugated podophyllotoxin prodrugs and fabricated their nanoparticles (GA-CN-PPT nano-prodrugs). GA-CN-PPT nano-prodrugs were obtained with a size of about 100 nm and possessed high dispersion stability. The cytotoxicity was tunable by changing the length of the carbon chain linker. Notably, the release rate of PPT was the key factor for the anticancer activity of GA-CN-PPT nano-prodrugs. The nano-prodrugs could serve as a promising template for developing a novel delivery system using nano-prodrugs.

本文言語英語
ジャーナルMolecular Crystals and Liquid Crystals
DOI
出版ステータス受理済み/印刷中 - 2022

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