@article{ea6254eb846a46b99ec5f542d5b59d4c,
title = "Design principles of a minimal auxin response system",
abstract = "Auxin controls numerous growth processes in land plants through a gene expression system that modulates ARF transcription factor activity1–3. Gene duplications in families encoding auxin response components have generated tremendous complexity in most land plants, and neofunctionalization enabled various unique response outputs during development1,3,4. However, it is unclear what fundamental biochemical principles underlie this complex response system. By studying the minimal system in Marchantia polymorpha, we derive an intuitive and simple model where a single auxin-dependent A-ARF activates gene expression. It is antagonized by an auxin-independent B-ARF that represses common target genes. The expression patterns of both ARF proteins define developmental zones where auxin response is permitted, quantitatively tuned or prevented. This fundamental design probably represents the ancestral system and formed the basis for inflated, complex systems.",
author = "Hirotaka Kato and Mutte, {Sumanth K.} and Hidemasa Suzuki and Isidro Crespo and Shubhajit Das and Tatyana Radoeva and Mattia Fontana and Yoshihiro Yoshitake and Emi Hainiwa and {van den Berg}, Willy and Simon Lindhoud and Kimitsune Ishizaki and Johannes Hohlbein and Borst, {Jan Willem} and Boer, {D. Roeland} and Ryuichi Nishihama and Takayuki Kohchi and Dolf Weijers",
note = "Funding Information: We thank the XALOC staff at the synchrotron ALBA and V. P. Carrillo, Carrasco, S. Kiryu, M. Katayama and L. Olijslager for experimental support, D. Gadella and K. Hiratsuka for providing materials, and O. Leyser for comments in the manuscript. This work was supported by an EMBO Long-term Fellowship (ALTF 415-2016) to H.K., a PhD fellowship from the Graduate School Experimental Plant Sciences to J.H. and D.W., a VICI grant (no. 865.14.001) from the Netherlands Organization for Scientific Research (NWO) to D.W., grants from the Ministry of Economy and Competitiveness of the Spanish Government (nos BIO2016-77883-C2-2-P and FIS2015-72574-EXP) (AEI/ FEDER,EU) to D.R.B., an ALW-open grant (no. ALWOP.402) from the NWO to J.W.B., JSPS/MEXT KAKENHI (grant nos 19K23751 to H.K., 18J12698 to H.S, 19K016166 to Y.Y., 17H06472 to K.I. 18H04836 to R.N. and 25113009, 15K21758 and 19H05675 to T.K.) and SPIRITS 2017 of Kyoto University to R.N. Publisher Copyright: {\textcopyright} 2020, The Author(s), under exclusive licence to Springer Nature Limited.",
year = "2020",
month = may,
day = "1",
doi = "10.1038/s41477-020-0662-y",
language = "English",
volume = "6",
pages = "473--482",
journal = "Nature Plants",
issn = "2055-026X",
publisher = "Palgrave Macmillan Ltd.",
number = "5",
}