Design, Synthesis, and Antifungal Activity of 16,17-Dihydroheronamide C and ent-Heronamide C

Naoki Kanoh, Ryusei Terashima, Hiromichi Nishiyama, Yuta Terajima, Shota Nagasawa, Yusuke Sasano, Yoshiharu Iwabuchi, Hiroaki Saito, Syusuke Egoshi, Kosuke Dodo, Mikiko Sodeoka, Chengqian Pan, Yoshinobu Ikeuchi, Shinichi Nishimura, Hideaki Kakeya

研究成果: ジャーナルへの寄稿学術論文査読

2 被引用数 (Scopus)

抄録

16,17-Dihydroheronamide C (8) and ent-heronamide C (ent-1) were designed as probes for the mode-of-action analysis of heronamide C (1). These molecules were synthesized by utilizing a highly modular strategy developed in the preceding paper. The evaluation of the antifungal activity of these compounds revealed the exceptional importance of the C16-C17 double bond for the antifungal activity of heronamide C and the existence of chiral recognition between heronamide C (1) and cell membrane components.

本文言語英語
ページ(範囲)16249-16258
ページ数10
ジャーナルJournal of Organic Chemistry
86
23
DOI
出版ステータス出版済み - 2021 12月 3

フィンガープリント

「Design, Synthesis, and Antifungal Activity of 16,17-Dihydroheronamide C and ent-Heronamide C」の研究トピックを掘り下げます。これらがまとまってユニークなフィンガープリントを構成します。

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