Determination of the toxicity equivalency factors for ciguatoxins using human sodium channels

Sandra Raposo-Garcia, M. Carmen Louzao, Haruhiko Fuwa, Makoto Sasaki, Carmen Vale, Luis M. Botana

研究成果: ジャーナルへの寄稿学術論文査読

10 被引用数 (Scopus)

抄録

Ciguatoxins (CTXs) which are produced by dinoflagellates of the genus Gambierdiscus and Fukuyoa and share a ladder-shaped polyether structure, are causative compounds of one of the most frequent foodborne illness disease known as ciguatera fish poisoning (CFP). CFP was initially found in tropical and subtropical areas but nowadays the dinoflagellates producers of ciguatoxins had spread to European coasts. Therefore, this raises the need of establishing toxicity equivalency factors for the different compounds that can contribute to ciguatera fish poisoning, since biological methods have been replaced by analytical techniques. Thus, in this work, the effects of six compounds causative of ciguatera, on their main target, the human voltage-gated sodium channels have been analyzed for the first time. The results presented here led to the conclusion that the order of potency was CTX1B, CTX3B, CTX4A, gambierol, gambierone and MTX3. Furthermore, the data indicate that the activation voltage of sodium channels is more sensitive to detect ciguatoxins than their effect on the peak sodium current amplitude.

本文言語英語
論文番号112812
ジャーナルFood and Chemical Toxicology
160
DOI
出版ステータス出版済み - 2022 2月

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