Duodenal Variceal Rupture during Atezolizumab and Bevacizumab Treatment for Hepatocellular Carcinoma

Mio Tsuruoka; Jun Inoue; Keishi Ouchi; Kaname Uno; Hideaki Itami; Masashi Ninomiya; Tomoaki Iwata; Akitoshi Sano; Kosuke Sato; Masazumi Onuki; Satoko Sawahashi; Tomoyuki Koike; Atsushi Masamune

doi:10.2169/internalmedicine.0629-22

Duodenal Variceal Rupture during Atezolizumab and Bevacizumab Treatment for Hepatocellular Carcinoma

Mio Tsuruoka, Jun Inoue, Keishi Ouchi, Kaname Uno, Hideaki Itami, Masashi Ninomiya, Tomoaki Iwata, Akitoshi Sano, Kosuke Sato, Masazumi Onuki, Satoko Sawahashi, Tomoyuki Koike, Atsushi Masamune

Tohoku University

研究成果: ジャーナルへの寄稿 › 学術論文 › 査読

4 被引用数 (Scopus)

抄録

Duodenal varices are detected infrequently, and their rupture is very rare. We encountered an 87-year-old man who developed duodenal varices rupture during chemotherapy with atezolizumab and bevacizumab (ATZ/BV) for hepatocellular carcinoma. We identified massive bleeding of a ruptured varix in the horizontal portion of the duodenum with emergency esophagogastroduodenoscopy (EGD). Successful hemostasis was achieved by endoscopic injection sclerotherapy with Histoacryl. Although ATZ/BV can cause esophageal varices rupture, there have been no cases of duodenal varices rupture. We should take care to check the duodenal varices as well as esophagogastric varices before ATZ/BV treatment.

本文言語	英語
ページ（範囲）	1467-1472
ページ数	6
ジャーナル	Internal Medicine
巻	62
号	10
DOI	https://doi.org/10.2169/internalmedicine.0629-22
出版ステータス	出版済み - 2023

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10.2169/internalmedicine.0629-22

他のファイルとリンク

Studies from Tohoku University Describe New Findings in Varicose Veins (Duodenal Variceal Rupture During Atezolizumab and Bevacizumab Treatment for Hepatocellular Carcinoma)
Koike, T., Masamune, A., Uno, K., Ninomiya, M. & Inoue, J.
23/6/28
1 次の項目: メディア掲載
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引用スタイル

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title = "Duodenal Variceal Rupture during Atezolizumab and Bevacizumab Treatment for Hepatocellular Carcinoma",

abstract = "Duodenal varices are detected infrequently, and their rupture is very rare. We encountered an 87-year-old man who developed duodenal varices rupture during chemotherapy with atezolizumab and bevacizumab (ATZ/BV) for hepatocellular carcinoma. We identified massive bleeding of a ruptured varix in the horizontal portion of the duodenum with emergency esophagogastroduodenoscopy (EGD). Successful hemostasis was achieved by endoscopic injection sclerotherapy with Histoacryl. Although ATZ/BV can cause esophageal varices rupture, there have been no cases of duodenal varices rupture. We should take care to check the duodenal varices as well as esophagogastric varices before ATZ/BV treatment.",

keywords = "HCC, atezolizumab and bevacizumab, duodenal varix, endoscopic injection sclerotherapy",

author = "Mio Tsuruoka and Jun Inoue and Keishi Ouchi and Kaname Uno and Hideaki Itami and Masashi Ninomiya and Tomoaki Iwata and Akitoshi Sano and Kosuke Sato and Masazumi Onuki and Satoko Sawahashi and Tomoyuki Koike and Atsushi Masamune",

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T1 - Duodenal Variceal Rupture during Atezolizumab and Bevacizumab Treatment for Hepatocellular Carcinoma

AU - Tsuruoka, Mio

AU - Inoue, Jun

AU - Ouchi, Keishi

AU - Uno, Kaname

AU - Itami, Hideaki

AU - Ninomiya, Masashi

AU - Iwata, Tomoaki

AU - Sano, Akitoshi

AU - Sato, Kosuke

AU - Onuki, Masazumi

AU - Sawahashi, Satoko

AU - Koike, Tomoyuki

AU - Masamune, Atsushi

PY - 2023

Y1 - 2023

N2 - Duodenal varices are detected infrequently, and their rupture is very rare. We encountered an 87-year-old man who developed duodenal varices rupture during chemotherapy with atezolizumab and bevacizumab (ATZ/BV) for hepatocellular carcinoma. We identified massive bleeding of a ruptured varix in the horizontal portion of the duodenum with emergency esophagogastroduodenoscopy (EGD). Successful hemostasis was achieved by endoscopic injection sclerotherapy with Histoacryl. Although ATZ/BV can cause esophageal varices rupture, there have been no cases of duodenal varices rupture. We should take care to check the duodenal varices as well as esophagogastric varices before ATZ/BV treatment.

AB - Duodenal varices are detected infrequently, and their rupture is very rare. We encountered an 87-year-old man who developed duodenal varices rupture during chemotherapy with atezolizumab and bevacizumab (ATZ/BV) for hepatocellular carcinoma. We identified massive bleeding of a ruptured varix in the horizontal portion of the duodenum with emergency esophagogastroduodenoscopy (EGD). Successful hemostasis was achieved by endoscopic injection sclerotherapy with Histoacryl. Although ATZ/BV can cause esophageal varices rupture, there have been no cases of duodenal varices rupture. We should take care to check the duodenal varices as well as esophagogastric varices before ATZ/BV treatment.

KW - HCC

KW - atezolizumab and bevacizumab

KW - duodenal varix

KW - endoscopic injection sclerotherapy

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U2 - 10.2169/internalmedicine.0629-22

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SN - 0918-2918

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SP - 1467

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JO - Internal Medicine

JF - Internal Medicine

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ER -

Duodenal Variceal Rupture during Atezolizumab and Bevacizumab Treatment for Hepatocellular Carcinoma

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プレス/メディア

Studies from Tohoku University Describe New Findings in Varicose Veins (Duodenal Variceal Rupture During Atezolizumab and Bevacizumab Treatment for Hepatocellular Carcinoma)

引用スタイル