@article{356e275efa864903b8ddce7d8f405535,
title = "Effect of agonal and postmortem factors on gene expression profile: Quality control in microarray analyses of postmortem human brain",
abstract = "There are major concerns that specific agonal conditions, including coma and hypoxia, might affect ribonucleic acid (RNA) integrity in postmortem brain studies. We report that agonal factors significantly affect RNA integrity and have a major impact on gene expression profiles in microarrays. In contrast to agonal factors, gender, age, and postmortem factors have less effect on gene expression profiles. The Average Correlation Index is proposed as a method for evaluating RNA integrity on the basis of similarity of microarray profiles. Reducing the variance due to agonal factors is critical in investigating small but validated gene expression differences in messenger RNA levels between psychiatric patients and control subjects.",
keywords = "Adenine-Uracil-rich elements, Bipolar disorder, Freezer interval, Iron-responsive element, Major depressive disorder, Postmortem interval",
author = "Hiroaki Tomita and Vawter, {Marquis P.} and Walsh, {David M.} and Evans, {Simon J.} and Choudary, {Prabhakara V.} and Jun Li and Overman, {Kevin M.} and Atz, {Mary E.} and Myers, {Richard M.} and Jones, {Edward G.} and Watson, {Stanley J.} and Huda Akil and Bunney, {William E.}",
note = "Funding Information: This project was supported by National Institute of Mental Health (NIMH) Conte Center Grant P50 MH60398, the Pritzker Neuropsychiatric Disorders Research Consortium, the William Lion Penzner Foundation (UCI), the Della Martin Foundation (UCI), NIMH Grant #MH54844 (EGJ), the W.M. Keck Foundation (EGJ), and NIMH Program Project MH42251 (SJW and HA). ",
year = "2004",
month = feb,
day = "15",
doi = "10.1016/j.biopsych.2003.10.013",
language = "English",
volume = "55",
pages = "346--352",
journal = "Biological Psychiatry",
issn = "0006-3223",
publisher = "Elsevier USA",
number = "4",
}