Effect of ambrisentan on peripheral circulation in patients with systemic sclerosis

Hayakazu Sumida; Yoshihide Asano; Masaru Hatano; Naohiko Aozasa; Tetsuo Toyama; Kaname Akamata; Miki Miyazaki; Takashi Taniguchi; Takehiro Takahashi; Yohei Ichimura; Shinji Noda; Yoshihiro Kuwano; Koichi Yanaba; Shinichi Sato

doi:10.3109/14397595.2014.885377

Effect of ambrisentan on peripheral circulation in patients with systemic sclerosis

Hayakazu Sumida, Yoshihide Asano, Masaru Hatano, Naohiko Aozasa, Tetsuo Toyama, Kaname Akamata, Miki Miyazaki, Takashi Taniguchi, Takehiro Takahashi, Yohei Ichimura, Shinji Noda, Yoshihiro Kuwano, Koichi Yanaba, Shinichi Sato

研究成果: Article › 査読

3 被引用数 (Scopus)

抄録

Systemic sclerosis (SSc) is characterized by disturbed blood circulation. The effect of ambrisentan, an endothelin-A receptor-selective antagonist, on impaired peripheral circulation in SSc remains largely elusive. Here we show SSc patients, whose clinical symptoms such as cyanosis and Raynaud's phenomenon, were ameliorated by the treatment with ambrisentan. Additionally, objective evaluations with thermography showed improvement of hand coldness in steady-state and cold challenge tests. Ambrisentan might have a potential to improve peripheral circulation in SSc.

本文言語	English
ページ（範囲）	454-457
ページ数	4
ジャーナル	Modern Rheumatology
巻	26
号	3
DOI	https://doi.org/10.3109/14397595.2014.885377
出版ステータス	Published - 2016 5月 3
外部発表	はい

ASJC Scopus subject areas

リウマチ学

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10.3109/14397595.2014.885377

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title = "Effect of ambrisentan on peripheral circulation in patients with systemic sclerosis",

abstract = "Systemic sclerosis (SSc) is characterized by disturbed blood circulation. The effect of ambrisentan, an endothelin-A receptor-selective antagonist, on impaired peripheral circulation in SSc remains largely elusive. Here we show SSc patients, whose clinical symptoms such as cyanosis and Raynaud's phenomenon, were ameliorated by the treatment with ambrisentan. Additionally, objective evaluations with thermography showed improvement of hand coldness in steady-state and cold challenge tests. Ambrisentan might have a potential to improve peripheral circulation in SSc.",

keywords = "Ambrisentan, Cyanosis, Raynaud's phenomenon, Systemic sclerosis, Thermography",

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AU - Sumida, Hayakazu

AU - Asano, Yoshihide

AU - Hatano, Masaru

AU - Aozasa, Naohiko

AU - Toyama, Tetsuo

AU - Akamata, Kaname

AU - Miyazaki, Miki

AU - Taniguchi, Takashi

AU - Takahashi, Takehiro

AU - Ichimura, Yohei

AU - Noda, Shinji

AU - Kuwano, Yoshihiro

AU - Yanaba, Koichi

AU - Sato, Shinichi

PY - 2016/5/3

Y1 - 2016/5/3

N2 - Systemic sclerosis (SSc) is characterized by disturbed blood circulation. The effect of ambrisentan, an endothelin-A receptor-selective antagonist, on impaired peripheral circulation in SSc remains largely elusive. Here we show SSc patients, whose clinical symptoms such as cyanosis and Raynaud's phenomenon, were ameliorated by the treatment with ambrisentan. Additionally, objective evaluations with thermography showed improvement of hand coldness in steady-state and cold challenge tests. Ambrisentan might have a potential to improve peripheral circulation in SSc.

AB - Systemic sclerosis (SSc) is characterized by disturbed blood circulation. The effect of ambrisentan, an endothelin-A receptor-selective antagonist, on impaired peripheral circulation in SSc remains largely elusive. Here we show SSc patients, whose clinical symptoms such as cyanosis and Raynaud's phenomenon, were ameliorated by the treatment with ambrisentan. Additionally, objective evaluations with thermography showed improvement of hand coldness in steady-state and cold challenge tests. Ambrisentan might have a potential to improve peripheral circulation in SSc.

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KW - Cyanosis

KW - Raynaud's phenomenon

KW - Systemic sclerosis

KW - Thermography

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Effect of ambrisentan on peripheral circulation in patients with systemic sclerosis

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