Effect of ambrisentan on peripheral circulation in patients with systemic sclerosis

Hayakazu Sumida, Yoshihide Asano, Masaru Hatano, Naohiko Aozasa, Tetsuo Toyama, Kaname Akamata, Miki Miyazaki, Takashi Taniguchi, Takehiro Takahashi, Yohei Ichimura, Shinji Noda, Yoshihiro Kuwano, Koichi Yanaba, Shinichi Sato

研究成果: ジャーナルへの寄稿学術論文査読

3 被引用数 (Scopus)

抄録

Systemic sclerosis (SSc) is characterized by disturbed blood circulation. The effect of ambrisentan, an endothelin-A receptor-selective antagonist, on impaired peripheral circulation in SSc remains largely elusive. Here we show SSc patients, whose clinical symptoms such as cyanosis and Raynaud's phenomenon, were ameliorated by the treatment with ambrisentan. Additionally, objective evaluations with thermography showed improvement of hand coldness in steady-state and cold challenge tests. Ambrisentan might have a potential to improve peripheral circulation in SSc.

本文言語英語
ページ(範囲)454-457
ページ数4
ジャーナルModern Rheumatology
26
3
DOI
出版ステータス出版済み - 2016 5月 3

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