Effect of concomitant use of valproic acid during clozapine initiation on clozapine-induced inflammation among Japanese patients with schizophrenia

Yuki Kikuchi, Hiroshi Komatsu, Yuji Otsuka, Fumiaki Ito, Yuji Yada, Hiroaki Tanifuji, Hiroaki Tomita

研究成果: ジャーナルへの寄稿学術論文査読

2 被引用数 (Scopus)

抄録

During clozapine initiation, titration speed and concomitant valproate administration have been reported as risk factors for clozapine-induced fever and myocarditis. We tested the risk of concomitant valproate administration by stratifying patients according to titration rate. Concomitant valproate use was only associated with increased inflammatory adverse events in the slower titration group. The frequency of inflammatory adverse events was approximately 30 % during faster titration, regardless of concomitant valproate administration. However, the faster titration group with valproate had a higher frequency of severe adverse effects such as myocarditis. Clinicians should avoid concomitant valproate administration during clozapine initiation, regardless of titration rate.

本文言語英語
論文番号115810
ジャーナルPsychiatry Research
334
DOI
出版ステータス出版済み - 2024 4月

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