Effect of the guideline education program on anticholinergic and benzodiazepine use in outpatients with schizophrenia and major depressive disorder: The effectiveness of guidelines for dissemination and education in psychiatric treatment (EGUIDE) project

Hirotaka Yamagata, Yuko Fujii, Shinichiro Ochi, Tomoe Seki, Naomi Hasegawa, Hisashi Yamada, Hikaru Hori, Kayo Ichihashi, Jun ichi Iga, Kazuyoshi Ogasawara, Naoki Hashimoto, Hitoshi Iida, Kazutaka Ohi, Takashi Tsuboi, Shusuke Numata, Akitoyo Hishimoto, Masahide Usami, Eiichi Katsumoto, Hiroyuki Muraoka, Yoshikazu TakaesuTatsuya Nagasawa, Hiroshi Komatsu, Kenichiro Miura, Junya Matsumoto, Ken Inada, Shin Nakagawa, Ryota Hashimoto

研究成果: ジャーナルへの寄稿学術論文査読

抄録

Reports on polypharmacy strategies for patients with schizophrenia and major depressive disorder (MDD) are scarce. The nationwide Effectiveness of Guidelines for Dissemination and Education in Psychiatric Treatment (EGUIDE) project has been used to train psychiatrists on the guidelines for treatment of schizophrenia and MDD. This study aimed to determine whether the EGUIDE program enabled more appropriate evidence-based treatment of outpatients with schizophrenia and MDD. The types and doses of all psychotropics were analyzed in 174 and 147 patients with schizophrenia and MDD, respectively, in 2018 before the EGUIDE program and in 2019 and 2020 after the program. There were no significant differences in the rate of monopharmacy with antipsychotics for schizophrenia; however, the prescriptions of first-generation antipsychotics, anticholinergics, and benzodiazepines for schizophrenia decreased significantly after the program. There were also no significant differences in antidepressant monopharmacy rates for MDD; however, the prescriptions of benzodiazepines in patients with MDD decreased significantly after the program. Significant positive correlations were found between the number of psychotropic prescriptions and dosage of benzodiazepines. In conclusion, the EGUIDE project has improved the prescribing behavior for outpatients with schizophrenia and depression. Therefore, the guideline training program may be useful for regulating the prescribing behavior among physicians.

本文言語英語
論文番号100158
ジャーナルPsychiatry Research Communications
4
1
DOI
出版ステータス出版済み - 2024 3月

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