@article{866f9dbf315247fe980eecece44018f8,
title = "Electrochemical imaging for single-cell analysis of cell adhesion using a collagen-coated large-scale integration (LSI)-based amperometric device",
abstract = "We here report the electrochemical imaging of cell adhesion using a large-scale integration (LSI)-based amperometric device, called a Bio-LSI device. The device consists of 400 sensor electrodes arranged with a pitch of 250μm. The device surface was modified with collagen to assist in the culture of MCF-7 cells and promote their adhesion. The cells disturb the electrochemical reaction of redox mediators, allowing the electrochemical signal to be used to evaluate cell adhesion at the single-cell level. This approach was applied to a cell detachment test. The results show that the Bio-LSI device is a promising tool for single-cell analysis.",
keywords = "Cell adhesion, Electrochemical imaging, LSI-based amperometric device, Single-cell analysis",
author = "Hiroya Abe and Yusuke Kanno and Kosuke Ino and Inoue, {Kumi Y.} and Atsushi Suda and Ryota Kunikata and Masahki Matsudaira and Hitoshi Shiku and Tomokazu Matsue",
note = "Funding Information: This work was supported in part by a Grant-in-Aid for Scientific Research (A) (No. 25248032), a Grant-in-Aid for Young Scientists (A) (No. 15H05415) and a Grant-in-Aid for Challenging Exploratory Research (No. 26600057) from the Japan Society for the Promotion of Science (JSPS). This work was also supported by Special Coordination Funds for Promoting Science and Technology, Creation of Innovation Centers for Advanced Interdisciplinary Research Areas Program from the Japan Science and Technology Agency. In addition, this work was also supported by the Asahi Glass Foundation, as well as by a Grant-in-Aid from the Tohoku University Institute for International Advanced Research and Education. Publisher Copyright: {\textcopyright} 2016 The Electrochemical Society of Japan, All rights reserved.",
year = "2016",
month = may,
doi = "10.5796/electrochemistry.84.364",
language = "English",
volume = "84",
pages = "364--367",
journal = "Electrochemistry",
issn = "1344-3542",
publisher = "Electrochemical Society of Japan",
number = "5",
}