Electron paramagnetic resonance study on nitric oxide production during brain focal ischemia and reperfusion in the rat

Shinya Sato, Teiji Tominaga, Tomoko Ohnishi, S. Tsuyoshi Ohnishi

研究成果: Article査読

79 被引用数 (Scopus)

抄録

The production of nitric oxide (NO) during brain focal ischemia and reperfusion was using diethyldithiocarbamate (DETC)/ Fe-citrate, NO trapping reagents, and electron paramagnetic resonance spectroscopy. The NO production is potentiated after 5 min of ischemia, and is continued during 60 min of ischemia. During the reperfusion period after 60 min of ischemia, NO was also produced. However, its production during reperfusion was not observed when the ischemia time was less than 15 min. The NO signal during reperfusion after 60 min of ischemia decreased after 15 min of reperfusion. These results suggest that NO production during ischemia is a physiological reaction for increasing cerebral blood flow, while NO production during reperfusion may be related to cellular damage.

本文言語English
ページ(範囲)91-96
ページ数6
ジャーナルBrain research
647
1
DOI
出版ステータスPublished - 1994 5月 30
外部発表はい

ASJC Scopus subject areas

  • 神経科学(全般)
  • 分子生物学
  • 臨床神経学
  • 発生生物学

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