Enhancement of in vitro gene transfection efficiency of adult stem cells by cationized polysaccharide derivatives

Jun Ichiro Jo; Masaya Yamamoto; Arimichi Okazaki; Tomonori Ikai; Yoshiaki Hirano; Yasuhiko Tabata

Enhancement of in vitro gene transfection efficiency of adult stem cells by cationized polysaccharide derivatives

Jun Ichiro Jo, Masaya Yamamoto, Arimichi Okazaki, Tomonori Ikai, Yoshiaki Hirano, Yasuhiko Tabata

研究成果: Paper › 査読

抄録

The technology to genetically manipulate adult stem cells has increasingly become important in terms of basic biological and medical researches on stem cells as well as cell therapy with genetically engineered cells. A non-viral gene carrier of polysaccharides with a cell specificity was explored by making use of sugar-recognition receptors on the cell surface for enhanced gene expression. Significantly higher gene expression by the polysaccharide carrier was achieved for bone marrow-derived stem cells than the LipofectAMINE™ commercially available.

本文言語	English
ページ	2142
ページ数	1
出版ステータス	Published - 2005
外部発表	はい
イベント	54th SPSJ Annual Meeting 2005 - Yokohama, Japan 継続期間: 2005 5月 25 → 2005 5月 27

Other

Other	54th SPSJ Annual Meeting 2005
国/地域	Japan
City	Yokohama
Period	05/5/25 → 05/5/27

ASJC Scopus subject areas

工学（全般）

他のファイルとリンク

引用スタイル

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AU - Jo, Jun Ichiro

AU - Yamamoto, Masaya

AU - Okazaki, Arimichi

AU - Ikai, Tomonori

AU - Hirano, Yoshiaki

AU - Tabata, Yasuhiko

PY - 2005

Y1 - 2005

N2 - The technology to genetically manipulate adult stem cells has increasingly become important in terms of basic biological and medical researches on stem cells as well as cell therapy with genetically engineered cells. A non-viral gene carrier of polysaccharides with a cell specificity was explored by making use of sugar-recognition receptors on the cell surface for enhanced gene expression. Significantly higher gene expression by the polysaccharide carrier was achieved for bone marrow-derived stem cells than the LipofectAMINE™ commercially available.

AB - The technology to genetically manipulate adult stem cells has increasingly become important in terms of basic biological and medical researches on stem cells as well as cell therapy with genetically engineered cells. A non-viral gene carrier of polysaccharides with a cell specificity was explored by making use of sugar-recognition receptors on the cell surface for enhanced gene expression. Significantly higher gene expression by the polysaccharide carrier was achieved for bone marrow-derived stem cells than the LipofectAMINE™ commercially available.

KW - Adult stem cells

KW - Cationized polysaccharide derivatives

KW - Gene transfection

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T2 - 54th SPSJ Annual Meeting 2005

Y2 - 25 May 2005 through 27 May 2005

ER -

Enhancement of in vitro gene transfection efficiency of adult stem cells by cationized polysaccharide derivatives

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ASJC Scopus subject areas

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